In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orodispersible tablets by using croscarmelloe sodiu...

The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioav...

The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. The...

The structural and physical stability of solid dispersions have not been adequately explored during spray drying manufacturing processes. In this study a wide range of compositions of naproxen/PVP-VA 64 (poly(1-vinylpyrrolidone-co-vinyl acetate)) and miconazole/PVP-VA 64 solid dispersions prepared by different laboratory spray dryers were collected from various selected locations and used to in...

poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. in this study, organic solvent-free solid dispersions (osf-sds) containing telmisartan (tel) were prepared using polyvinylpyrrolidone k30 (pvp k30) and polyethylene glycol 6000 (peg 6000) as hydrophilic polymers, sodium hydroxide (naoh) as an alkalizer, and ...

in the present study solid dispersions of the antifungal drug ketoconazole were prepared with pluronic f-127 and pvp k-30 with an intention to improve its dissolution properties. investigations of the properties of the dispersions were performed using release studies, differential scanning calorimetery (dsc), x-ray powder diffraction (xrd) and fourier transform infrared (ftir). the results obta...

PURPOSE Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion. METHODS Spironolactone solid dispersions (1:1, 1:2 and 2:1 drug: carrier weight ratio) were prepared by polyethylene glycol (PEG) 6000 as a carrier by hot melt...

The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium by the solid dispersion technique using modified locust bean gum. Solid dispersions (SD) using modified locust bean gum were prepared by the modified solvent evaporation method. Other mixtures were also prepared by physical mixing, co-grinding, and the kneading method. The locust bean gum was subje...