In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v, constant) of selected water-soluble substances from among the hydrotropes (urea, sodium benzoate, sodium citrate, nicotinamide); water-soluble solids (PEG-...

• The Body's Need for Vitamins and Minerals in the Diet • Molecular Basis for Water Solubility and Fat Solubility (e.g., of Vitamins) Polarity of Solvent and Solute Thermodynamics of Dissolution • Structures and Functions of Key Vitamins • Effect of Olestra (Artificial Fat) on Vitamin Solubility • Quantitative Measures of Mineral Solubility Solubility Product (Ksp) Solubility (S) • Calcium in t...

The solubility of tris(pentane-2,4-dionato)chromium(III) (Cr(acac)(3)) in supercritical carbon dioxide (SC-CO(2)) containing organic modifiers (1,1,1,3,3,3-hexafluoro-2-propanol (HFP) and 3,5-bis(trifluoromethyl)phenol (BTMP)) of hydrogen-bond donors was investigated by UV/VIS spectrophotometry. A great solubility enhancement of Cr(acac)(3) in SC-CO(2) was accomplished by adding HFP and BTMP. T...

A model aquatic ecosystem is devised for studying relatively volatile organic compounds and simulating direct discharge of chemical wastes into aquatic ecosystems. Six simple benzene derivatives (aniline, anisole, benzoic acid, chlorobenzene, nitrobenzene, and phthalic anhydride) and other important specialty chemicals: hexachlorobenzene, pentachlorophenol, 2,6-diethylaniline, and 3,5,6-trichlo...

1. Pepsin solutions were iodinated at pH 5.0-6.0 until 10-20 per cent of the activity was lost and 1/20 (0.7 per cent) of the saturating amount of iodine had been introduced into the protein molecule. After alkaline hydrolysis 65 per cent of the original iodine was accounted for as mono-iodotyrosine although only 42 per cent was isolated as a crystalline product. No evidence was obtained to sup...