1William Beaumont Hospital, Royal Oak, Michigan; 2University of Arkansas for Medical Sciences, Little Rock, Arkansas; 3New York Hospital–Cornell Medical, New York, New York; 4University of Cincinnati Medical Center, Cincinnati, Ohio; 5Erasmus University Medical Center, Rotterdam, The Netherlands; 63rd Medical School, Charles University, Prague, Czech Republic; 7Northwestern University, Chicago,...

A new treatment modality for inoperable or metastasized gastroenteropancreatic tumors is the use of radiolabeled somatostatin analogs. Initial studies with high doses of [(111)In-diethylenetriaminepentaacetic acid (DTPA)(0)]octreotide in patients with metastasized neuroendocrine tumors were encouraging, although partial remissions were uncommon. Another radiolabeled somatostatin analog that is ...

In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma, successful treatment with the somatostatin analog octreotide was conducted during the first month and the second half of pregnancy without side-effects on placental and fetal development. As ...

Somatostatin is a potent inhibitor of gastrin secretion and gene expression. Menin is a 67-kDa protein product of the multiple endocrine neoplasia type 1 (MEN1) gene that when mutated leads to duodenal gastrinomas, a tumor that overproduces the hormone gastrin. These observations suggest that menin might normally inhibit gastrin gene expression in its role as a tumor suppressor. Since somatosta...

BACKGROUND Somatostatin analogs induce alterations in sleep in healthy adults. Presently, it is unknown whether somatostatin analog treatment affects sleep parameters in patients with acromegaly. DESIGN Case-control study. PATIENTS AND MEASUREMENTS We assessed sleepiness and sleep patterns in 62 adult patients (32 men, age 61 years (33-88 years) controlled by surgery alone or postoperative ...

The development of a long-acting delivery system for D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160), an octapeptide analog of somatostatin, required the establishment of a method for determining the concentration of this analog in serum during treatment. A sensitive and specific radioimmunoassay (RIA) for RC-160 was developed and used for following the rate of liberation of this peptide from ...

William Beaumont Hospital, Royal Oak, Michigan; New York Hospital–Cornell Medical, New York, NY; Mallinckrodt Institute of Radiology, St. Louis, Missouri; University of Cincinnati Medical Center, Cincinnati, Ohio; Beth Israel Deaconess Medical Center, Boston, Massachusetts; University Hospital Dijkzigt, Rotterdam, The Netherlands; and Third Medical School, Charles University, Prague, Czech Repu...