In this study the enhancement effect of Sophora pachycarpa roots' acetone extract on the antibacterial activity of gentamycin was evaluated against Staphylococcus aureus. Disc diffusion and broth dilution methods were used to determine the antibacterial activity of gentamycin in the absence and presence of plant extract and its various fractions separated by TLC. A clinical isolate of S. aureus...

Taxonomic patterns in the distribution of alkaloids, phenolic compounds and cyanogenic glycosides in the genistoid group, which includes the tribes Brongniartieae, Genisteae, Thermopsideae, Crotalarieae, Podalyrieae, Euchresteae and part of the Sophoreae, are reviewed. Discontinuities in the distribution of secondary metabolites agree well with recent modifications to generic and tribal delimit...

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels i...

objective(s): evaluation of the sophora alopecuroides var. alopecuroides seed effects on morphine withdrawal syndrome in mice and determination of the alkaloid composition of the seed total extract. materials and methods:the effects of the seed total extract, alkaloid fraction and major compound matrine on the mice morphine withdrawal syndrome were compared to saline and methadone.mice were mad...

The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner i...

A new isoflavonolignan glycoside, butesuperin B-7''-O-β-glucopyranoside (1) along with a known isoflavonolignan butesuperin A (2), were isolated from the roots of Sophora tonkinensis. The structure of the new compound was elucidated using spectroscopic methods, mainly 1D and 2D NMR. Compound 1 showed week cytotoxicity against BEL-7404 and NCI-H460 cells in MTT assay.