objective(s) the aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of peg400 as plasticizer. materials and methods polyethylene glycol (peg400) in concentrations of 1, 3 or 5% w/w with respect to eudragit rl was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

objective(s): this study evaluates the effect of substitution of microcrystalline cellulose (mcc) with ethylcellulose (ec) on mechanical and release characteristics of theophylline pellets. materials and methods: the effect of addition of ec was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. also the effect of type of granulating liqui...

The present study aims at discussing the potential advantages of multiple unit dosage forms (pellets etc.) over the single unit dosage forms (tablets). Pelletization is a novel drug delivery system; a technique which converts fine powder particles into pellets. Review deals with the pellet and its various types of pelletization techniques like spheronization and extrusion, pelletization by laye...

The aim of this study was to develop a pH responsive enteric coated extended release multiparticulate dosage form containing a model drug ketoprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets in matrix form were prepared by using extrusion/spheronization method. The optimized pelletization method revealed that extrusion using 1 mm sieve plate a...

Furosemide is a class IV biopharmaceutical classification system drug having poor water solubility and low bioavailability due to the hepatic first-pass metabolism and has a short half-life of 2 h. To overcome the above drawback, this study was carried to prepare and evaluate the pellets containing furosemide solid dispersion (SD) for oral administration prepared by extrusion/spheronization. SD...