STUDY DESIGN The aim of this study is to test the effect of cartilage oligomeric matrix protein (COMP) on enhancing rhBMP-2 induced spinal fusion in a prospective 8-week interventional trial of spinal fusion in rats. OBJECTIVE To determine whether the amount of bone morphogenetic protein-2 (BMP-2) required to achieve spinal fusion in a pre-clinical model can be reduced by the addition of COMP...

Three cases of postoperative lumbar spinal canal stenosis due to anterior spinal fusion were reported. In these cases stenosis occurred at the adjacent intervertebral disc level of the fused segment a considerable time after anterior spinal fusion performed for spondvlolisthesis. At the stenotic level of the lumbar spinal canal, hypertrophy of the lamina, body spur formation in the articular pr...

 Abstract Background: Correction of severe kyphosis is a challenging operation in spinal surgery. A two stage operation has been commonly used: anterior release and decompression followed by posterior correction and fusion. We describe the posterior vertebral osteotomy technique for correction of severe and rigid kyphosis through posterior-only approach. Methods: Twelve patients (six male and s...

BACKGROUND Few studies have explored the effects of bisphosphonates on bony healing in patients undergoing spinal fusion surgery. Most previous studies used animal models and found that bisphosphonate shows negative effects on spinal fusion consolidation. We intended to evaluate the effect of a single-dose of zoledronic acid on the volume of the fusion-mass in lumbar spinal fusion. METHODS A ...

It is well known that high rates of fusion failure and pseudoarthrosis development (5~35%) are concomitant in spinal fusion surgery, which was ascribed to the shortage of suitable materials for bone regeneration. Citrate was recently recognized to play an indispensable role in enhancing osteconductivity and osteoinductivity, and promoting bone formation. To address the material challenges in sp...

abstract background: correction of severe kyphosis is a challenging operation in spinal surgery. a two stage operation has been commonly used: anterior release and decompression followed by posterior correction and fusion. we describe the posterior vertebral osteotomy technique for correction of severe and rigid kyphosis through posterior-only approach. methods: twelve patients (six male and si...

OBJECTIVE The purpose of this study was to examine the efficacy and perioperative complications associated with lumbar spinal fusion surgery, focusing on geriatric patients in the Republic of Korea. METHODS We retrospectively investigated 485 patients with degenerative spinal diseases who had lumbar spinal fusion surgeries between March 2006 and December 2010 at our institution. Age, sex, com...

Purpose Parkinson’s Disease (PD) patients are a high-risk population in adult spinal surgery and there is no general consensus regarding the surgical correction of spinal deformity in these patients. We perform long fusion for PD spinal deformity in our institution and this study is a retrospective assessment of the radiological and clinical outcomes of posterior spinal fusion with instrumentat...

Purpose To report indications, outcomes and complications of instrumented cervical spinal fusion in a consecutive series of children at major university hospitals. Methods A retrospective, single surgeon series identified 35 consecutive children with a mean follow-up (FU) of 2.5 years undergoing instrumented cervical spinal fusion between 2005 and 2015. Results The main indications were ske...

BACKGROUND Lumbar spinal stenosis is the most common reason for spinal surgery in elderly patients. However, the surgical management of spinal stenosis is controversial. The aim of this review was to list aspects a surgeon considers when choosing a specific type of treatment. METHODS Appraisal of arguments reported in randomized controlled trials (RCTs) included in systematic reviews publishe...