1Departments of Medicine and Dermatology, Division of Immunology and Rheumatology, Stanford University and Palo Alto VA Health Care System, CA, USA; 2Centre for Rheumatology, Royal Free Hospital, London, United Kingdom; 3Department of Rheumatology, University Hospital Zurich, Switzerland; 4Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, US...

Résumé. Cet article se place dans le cadre du subspace clustering, dont la problématique est double : identifier simultanément les clusters et le sousespace spécifique dans lequel chacun est défini, et caractériser chaque cluster par un nombre minimal de dimensions, permettant ainsi une présentation des résultats compréhensible par un expert du domaine d’application. Les méthodes proposées jusq...

P.N. Appleton (IPAC), A.W. Blain (Caltech), C.M. Bradford (JPL), C.R. Bridge (SSC), R. Chary (SSC), E. Daddi (CEA Saclay), V. Desai (SSC), M. Harwit (Cornell), G. Helou (IPAC), P.F. Hopkins (UC Berkeley), M. Malkan (UCLA), J. Melbourne (Caltech), E.J. Murphy (SSC), P. Ogle (SSC), C. Papovich (Texas A&M), A. Pope (NOAO), D. Riechers (Caltech), J.R. Rigby (OCIW), J.D. Smith (Toledo), G. Stacey (C...

Systemic sclerosis (SSc) is a connective tissue disease that is characterized by tissue fibrosis, microvasculopathy, and autoimmunity. Interstitial lung disease (ILD) is a common complication of SSc and is one of the frequent causes of mortality in SSc. Although the exact etiology of SSc remains unknown, clinical and experimental investigations have suggested that genetic and environmental fact...

Sparse Subspace Clustering (SSC) has been used extensively for subspace iden-tification tasks due to its theoretical guarantees and relative ease of implemen-tation. However SSC has quadratic computation and memory requirementswith respect to the number of input data points. This burden has prohibitedSSCs use for all but the smallest datasets. To overcome this we propose a n...

OBJECTIVE SSc is characterized by microvascular abnormalities and leucocyte infiltration. Previous studies have suggested a proadhesive phenotype in SSc skin, but the functional consequences of this phenotype are not fully understood. Molecules known to mediate leucocyte adhesion include those present at intracellular junctions, such as junctional adhesion molecule-B (JAM-B), JAM-C and CD99, as...

INTRODUCTION Systemic sclerosis (SSc) is characterized by fibrosis and microvascular abnormalities including dysregulated angiogenesis. Chemokines, in addition to their chemoattractant properties, have the ability to modulate angiogenesis. Chemokines lacking the enzyme-linked receptor (ELR) motif, such as monokine induced by interferon-γ (IFN-γ) (MIG/CXCL9) and IFN-inducible protein 10 (IP-10/C...

Saikosaponin C (SSC) is one of the major active constituents of dried Radix bupleuri root (Chaihu in Chinese) that has been widely used in China to treat a variety of conditions, such as liver disease, for many centuries. The binding of SSC to human serum albumin (HSA) was explored by fluorescence, circular dichroism (CD), UV-vis spectrophotometry, and molecular docking to understand both the p...

Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations. SSc is considered to be the prototypic systemic fibrotic disorder. Despite currently available therapeutic approaches SSc has a high mortality rate owing to the development of SSc-associated interstit...