Content-based image retrieval (CBIR) retrieves database images most similar to the query image by (1) extracting quantitative image descriptors and (2) calculating similarity between database and query image descriptors. Recently, manifold learning (ML) has been used to perform CBIR in a low dimensional representation of the high dimensional image descriptor space to avoid the curse of dimensio...

PURPOSE The incorporation of doxorubicin in long-circulating sterically stabilized liposomes (SSL-DXR) alters the pharmacokinetics and biodistribution of doxorubicin and therefore has the potential to alter the pharmacologic properties of doxorubicin. Previously, we showed that repetitive administration of SSL-DXR alters tumor vascular permeability. EXPERIMENTAL DESIGN Here, we investigated t...

If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples; however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintainin...

As a major family of semi-supervised learning (SSL), graph-based SSL has recently attracted considerable interest in the machine learning community along with application areas such as video semantic analysis. In this paper, we analyze the connections between graph-based SSL and partial differential equation(PDE) based diffusion. From the viewpoint of PDE-based diffusion, the label propagation ...

In the present study, we prepared NGR-modified sterically stabilized liposomes containing paclitaxel (NGR-SSL-PTX) in order to evaluate their potential targeting to aminopeptidase N receptors expressed on tumor endothelial cells and the tumor cell surface and its anti-angiogenic activity following metronomic administration. NGR-SSL-PTX was prepared by a thin-film hydration method. The in vitro ...

Average users lack the technical expertise to understand SSL certificates and security is not their primary goal. Thus, it is very hard to create a notable impact on user behavior using SSL-status indicators. However, with the introduction of web browser Personas (simple skins) as a possibility to change the browser's chrome, it becomes possible to provide a large status indicator without wasti...

The encryption of network traffic complicates legitimate network monitoring, traffic analysis, and network forensics. In this paper, we present real-time lightweight identification of HTTPS clients based on network monitoring and SSL/TLS fingerprinting. Our experiment shows that it is possible to estimate the User-Agent of a client in HTTPS communication via the analysis of the SSL/TLS handshak...

In the present study, we prepared a novel delivery system of iRGD (CRGDK/RGPD/EC)-modified sterically stabilized liposomes (SSLs) containing conjugated linoleic acid-paclitaxel (CLA-PTX). The anti-tumor effect of iRGD-SSL-CLA-PTX was investigated on B16-F10 melanoma in vitro and in vivo. The in vitro targeting effect of iRGD-modified SSLs was investigated in a real-time confocal microscopic ana...

Secure Session Layer (SSL) and Transport Layer Security (TLS) are the two secure layer protocols in all of current web applications on a network. This paper focuses on SSL, TLS and how handshaking mechanism has been implemented in both SSL and TLS. Further, describes about the generation of keys and certificates.