Some women in childbearing ages take selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and fluvoxamine for treating psychiatric symptoms. However, these compounds may cause some side effects to their children. It has been identified that early life exposure to SSRIs increased the chance of developing mood disorders and the biological basis is still unclear. Here, we studied the...

BACKGROUND Recent studies have reported conflicting results on the association between selective serotonin reuptake inhibitors (SSRIs) and the risk of heart defects. We aimed to assess the association between SSRIs in pregnant women during the first trimester and the risk of congenital heart defects. METHODS AND RESULTS PubMed and EMBASE up to July 2014 were searched for population-based coho...

In this report, recommendations for the pharmacological treatment of anxiety and obsessive-compulsive disorders are presented, based on available randomized, placebo- or comparator-controlled clinical studies. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for panic disorder. Tri2-cyclic antidepressants (TCAs) are equally effective, but they are less well tolerated...

Tricyclic antidepressants TCAs) are no longer widely prescribed as first choice treatments for depression. In their place have come the selective serotonin reuptake inhibitors (SSRIs). Sales of SSRIs and other new antidepressants have grown massively partly at the expense of tricyclics and partly because of burgeoning antidepressant prescribing in general (Lawrenson et al, 2000; Middleton et al...

Selective serotonin reuptake inhibitors (SSRIs) are associated with significant sexual side effects. By definition, all SSRIs increase overall serotonin (5HT) by binding to serotonin autoreceptors (5HT(IA)); however, each SSRI has a unique portfolio of secondary binding properties to other neurotransmitters such as norepinephrine (NE). As 5HT(IA) receptors mediate NE neurotransmission, SSRIs th...

There is a controversy about the use of SSRIs in the treatment of depressive disorders'in children and adolescents. Media concern that SSRIs might precipitate suicidal acts in teenagers was highlighted in a BBC Panorama programme (BBC News, 2003). Shortly afterwards, the pharmaceutical companies GlaxoSmithKline and Wyeth issued warnings about their products Paroxetine and Venlafaxine. In Decemb...

S elective serotonin reuptake inhibitors (SSRIs) are used commonly to treat poststroke depression. They are also being evaluated in clinical trials for their effectiveness in facilitating functional recovery after stroke. 3,4 However, observational studies suggest that SSRIs are associated with several adverse outcomes in older people (aged >65 years), including an increased risk of all-cause m...

INTRODUCTION Several small studies have reported inconsistent findings about the safety of selective serotonin reuptake inhibitors (SSRIs) among patients undergoing coronary artery bypass grafting (CABG). We sought to investigate post-CABG bleeding and mortality outcomes related to antidepressant exposure. METHODS We identified patients who underwent CABG between 2004 and 2008 in the Premier ...

BACKGROUND A meta-analysis of the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried out. METHODS Efficacy data from 102 randomised controlled trials (10706 patients) were pooled to provide a summary variance-weighted effect size. Tolerability data from 95 studies (10553 patients) were combine...