When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin discriminates among its many potential cargo molec...

DOI: 10.1002/advs.201700872 Who would have believed it? When we launched Advanced Science in December 2014, everyone in the editorial team agreed that it was a fantastic idea to create a forum for top science, open to read, download, and share with everyone, but the development that this young journal has undergone during the last three years has stunned even the most optimistic among us. Figur...

The membership committee of the American Academy of Pedodontics is endeavoring to provide information to new pedodontists about starting a practice. This article in,dudes several factors to consider in preparing a practice. They are: 1. Choosing a dental practice arrangement 2. Selecting and planning a solo practice 3. Choosing an area 4. Choosing a practice facility 5. Finding support services...