background: it was intended to investigate the effect of physical wedge (pw) and enhanced dynamic wedges (edw) on contralateral breast dose during primary breast irradiation in radiotherapy treatment, using high energy photon beams. materials and methods: the varian’s clinac dual mode linear accelerator model 2100 c/d and siemen’s primus accelerators were used for radiation doses with 6 mv and ...

Since the FDA approved sorafenib use for thyroid cancer, administration of this medicine to thyroid-cancer patients had steadily increased. However, an appropriate starting dose for this treatment has not been established, which is problematic because the sorafenib discontinuation rate due to toxicity is higher among thyroid cancer patients than among patients with other solid tumors. We recent...

BACKGROUND Lead is a highly toxic and pervasive metal. Chronic exposure to low levels is responsible for significant health effects, particularly in children. Prevention remains the best option for reducing childhood lead exposure, however the knowledge, attitudes and practices to lead exposure in many developing countries is not known. METHODS We conducted four focus group discussions (FGD) ...

in this report we explain a case of primary hyperparathyroidism in a 45 years old diabetic woman that was initially presented with recurrent nephrolithiasis of more than 10 years duration leading to right complete and left partial nephrectomy and complicated by end-stage renal failure. after diagnosis of primary hyperparathyroidism and parathyroid adenectomy, she developed severe hypocalcaemia ...

PURPOSE We sought to better understand how dose and titration with duloxetine treatment may impact tolerability and treatment discontinuation in patients with major depressive disorder. PATIENTS AND METHODS We investigated Phase III duloxetine trials. Group 1 was a single placebo-controlled study with a 20 mg initial dose and a slow titration to 40 and 60 mg. Group 2 was a single study with a...

New British guidelines on the treatment of asthma (9) advocate starting with a higher dose of inhaled corticosteroids in newly detected asthma patients. We investigated whether initiating inhaled steroid treatment with a higher dose is clinically more effective than a lower dose in steroid naive patients with asthma. The study had a 13-wk randomized, double-blind, parallel design: 1-mo treatmen...

starting treatment of chronic indolent conditions at doses lower than those typically recommended in the product monographs. The approach we recommend is to use a very low dose when starting a new medication if the condition is not life-threatening or producing severe symptoms. Unfortunately, this approach is not used that much in practice. First, we should define “very low dose.” The “start lo...