Continuous manufacturing has received increasing interest because of the advantages intrinsic safety and enhanced mass transfer in pharmaceutical industry. However, difficulty for scale-up limited application continuous a long time. Recently, tubular flow reactor equipped with Kenics static mixer appears to be solution process scale-up. Although many influence factors on mixing performance have...

Introduction: Microfluidic formulation of liposomes has been extensively studied as a potential replacement for batch methods, which struggle with problems in scalability and difficulty modulating conditions. Although microfluidic devices are considered to be able combat these issues, an adequate method yet established. Methods: This paper examines the static mixer (SM) by comparing encapsulati...

The effect of an in-mold static mixer on orientation fiber-reinforced polypropylene (PP) was explored within the injection molding process. Several mold geometries and helical designs were assessed via simulation to identify mixing ability potential fiber orientation. It found that mixers runner segment could successfully mix polymer randomize fibers but alignment reduction quickly recovered. I...