3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate-limiting enzyme in cholesterol biosynthesis. Several large landmark clinical studies have shown a marked reduction of cardiovascular mortality and morbidity in patients treated with statins. Because of the strong association between serum cholesterol levels and coronary artery diseas...

Statins, besides being powerful cholesterol-lowering drugs, also exert potent anti-proliferative activities. However, their anti-cancer efficacy differs among the individual statins. Thus, the aim of this study was to identify the biological pathways affected by individual statins in an in vitro model of human pancreatic cancer. The study was performed on a human pancreatic cancer cell line Mia...

BACKGROUND Although statins have been shown to reduce the risk of cardiovascular events in patients at low cardiovascular risk, their absolute benefit is small in the short term, which may adversely affect cost-effectiveness. We sought to determine the long-term cost-effectiveness (beyond the duration of clinical trials) of low- and high-potency statins in patients at low cardiovascular risk an...

BACKGROUND Data on the lowering effects of statins in hypertensive patients have been mixed and highly controversial. Some studies shows reductions effects of statins in blood pressure, whereas others do not. The evidence in the literature on the effects of statins on blood pressure raises the possibility that statins may directly lower blood pressure in addition to reduce cholesterol levels-pl...

BACKGROUND Statins are extensively used for cardiovascular disease prevention. Statins reduce mortality rates more than other lipid-modulating drugs, although evidence from randomized controlled trials also suggests that statins unexpectedly increase the risk of diabetes and improve immune function. Physiologically, statins would be expected to lower androgens because statins inhibit production...

An increasing number of studies have supported that high cholesterol is a risk factor for the pathogenesis of Alzheimer's disease ( AD ), including beta-amyloid peptides ( Aβ ) pathology. Clinical and biomolecular research studies have accumulated that statins, cholesterol-lowering drugs, could stave off the symptoms of AD and have seemed one of the most promising drugs in the war against AD. T...

34 BACKGROUND Statin medications lower serum cholesterol by competitively inhibiting HMG-CoA reductase. By this mechanism, statins effectively lower LDL cholesterol and reduce the risk of ischemic heart disease and stroke. The relative safety of statins has led to their widespread use, but recent research suggests that statins may have additional important therapeutic effects via other molecula...

Background: Statins have a pleiotropic effect in addition to lipid-lowering effect. Several studies demonstrated that statins may reduce the mortality and severity of infectious diseases, such as pneumonia or sepsis. We investigated protective effects various on coronavirus disease 2019 (COVID-19) using population-based cohort covering entire Korean population. Methods: Consecutive patients dia...