PURPOSE To analyze the sensitivity of various sensory tests adjusted for glaucomatous optic disc damage. METHODS In a cross-sectional study, the results of testing of 196 control subjects (age range, 18-69 years) and 308 patients with chronic open-angle glaucoma (age range, 18-70 years) were included. The perimetric mean defect (MD), a temporal contrast sensitivity test (TCS), a spatiotempora...

Purpose Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). Methods Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed...

In recent years we have experienced an increase in the usage of tags to describe resources. However, the free nature of tagging presents some challenges regarding the search and exploration of tag spaces. In order to deal with these challenges we propose the Semantic Tag Clustering Search (STCS) framework. The framework first groups syntactic variations using several measures based on the Leven...

With the increasing maturity of systems thinking and complexity science (STCS) within evaluation, this issue NDE provides case examples contemporary application. This article identifies themes across to identify emergent patterns opportunities for continued development evaluation practices that draw upon STCS. Each describes STCS its applications specific contexts. Our review cases identified t...

BACKGROUND Percutaneous access to the jejunum is an important approach if gastrostomy feeding is not possible. OBJECTIVE To analyze success, short- and long-term complications (STCs, LTCs) in patients with percutaneous endoscopic jejunostomy (PEJ) and jejunal access through percutaneous endoscopic gastrostomy (Jet-PEG). METHODS A retrospective analysis of endoscopically placed PEJs and Jet-...

By analyzing a set of the Coupled Model Intercomparison Project phase 3 (CMIP3) climate model projections of the twenty-first century, it is found that the shallow meridional overturning of the Pacific subtropical cells (STCs) show contrasting trends between two hemispheres in a warming climate. The strength of STCs and equivalently the STC surface-layer transport tend to be weakening (strength...

Despite the increasing literature, applications, and discussions over last 15 years, there remain questions about how to bring systems thinking complexity science (STCS) into evaluation in ways that meaningfully enhance its practice, use, results. One pathway forward is bridging gap between large STCS body of knowledge practice by synthesizing insights actionable frameworks support work role th...

This paper highlights three aspects in order to assist understanding of ethical entrepreneurship. First, it points out that ethical considerations enter at the individual and macro level of society, to impact on the running of business. Second, ethical imperatives are examined within a constrained entrepreneurship framework. Operating ethically presents opportunity albeit within constraint. Thi...

In this thesis we propose the Semantic Tag Clustering Search framework (STCS). This framework consists of three parts. The first part deals with syntactic variations by clustering tags that are syntactic variations of each other and assigning a label to them. The second part of the framework addresses the problem of recognizing homonyms and identifying semantically related tags. The last, and f...

BACKGROUND Regional differences in the care of severely injured patients remain problematic in industrial countries. METHODS In 2006, the German Society for Trauma Surgery initiated the foundation of regional networks between trauma centers in a TraumaNetwork (TNW). The TNW consisted of five major elements as follows: (a) a whitebook on the treatment of severely injured patients; (b) evidence...