In this paper, we present a novel approach, stealth multicast, which offers a practical solution for the adoption of network-level IP multicast. Rather than focusing on a global scale such as with previous approaches, stealth multicast optimizes efficiency on a domain-wise scale. In short, stealth multicast dynamically combines redundant data payloads into virtual groups for multicast transmiss...

Stealth navigation is a fundamental capability for a scout vehicle to e ectively perform reconnaissance missions. One component of stealth is the ability to plan paths that minimize visibility of the vehicle from target locations. This paper demonstrates a stealth planning system using visibility analysis on digital terrain elevation maps for path planning. Goal locations can be user speci ed o...

There are a variety of bacterial defense strategies to survive in a hostile environment. Generation of extracellular polysaccharides has proved to be a simple but effective strategy against the host's innate immune system. A comparative genomics approach led us to identify a new protein family termed Stealth, most likely involved in the synthesis of extracellular polysaccharides. This protein f...

Background Immune checkpoint inhibitors (CIs) have emerged as a revolutionary treatment for several cancer types. Despite significant improvement in prognosis some patients, there are associated challenges. CIs do not work well on immune-cold tumors, thereby eliciting an insufficient immune response. They also effective tumors with low mutational burden due to dependance tumor self-antigens rec...

Major advances in the use of liposomes, conjugates, nanoparticles, and microspheres as vehicles delivering pharmacologic agents and enzymes to sites of disease have occurred in the past 10 years (1–3). Pegylated-STEALTH liposomal doxorubicin (Doxil, Caelyx) was the first liposomal anticancer drug to be approved by the Food and Drug Administration, whereas paclitaxel albumin-bound particle suspe...

Liposome mediated anticancer drug delivery has the advantage of reducing cytotoxicity in healthy tissues. However, undesired slow drug release impedes the therapeutic efficacy of clinically applied PEG-liposomal doxorubicin (Dox). The aim of this study is to combine stealth thermosensitive liposomes (TSL) and local mild hyperthermia (HT) to increase bioavailable Dox levels in tumors. Dox was en...

We encapsulated cisplatin into stealth pH-sensitive liposomes and studied their stability, cytotoxicity and accumulation in a human small-cell lung carcinoma cell line (GLC4) and its resistant subline (GLC4/CDDP). Since reduced cellular drug accumulation has been shown to be the main mechanism responsible for resistance in the GLC4/CDDP subline, we evaluated the ability of this new delivery sys...

Stealth assessment provides an innovative way to assess and ultimately support knowledge, skills, and other personal attributes within learning or gaming environments without disrupting students’ flow. In this paper, we briefly discuss two challenges we encountered during the development of stealth assessments in two past projects (i.e., utility issues related to log files and validation issues...