Citation: Lee HK, Bae Y-S. 12th International Dendritic Cell Symposium, October 7–11, 2012; Daegu, Korea: New paradigm of dendritic cell science and application. OncoImmunology 2013; 2:e23245 The 12th International Dendritic Cell (DC) symposium (DC2012, www. DC2012.kr), organized by Ho-Youn Kim (President), Hyunah Lee (Secretary General), and Yong-Soo Bae (Scientific Program Organizer), was hel...

The 2011 Noble Prize in Physiology or Medicine was awarded to Bruce A. Beutler, Jules A. Hoffmann and Ralph M. Steinman for their groundbreaking research within immunology. Bruce A. Beutler and Jules A. Hoffmann were recognized for their discoveries on Toll and Toll-like receptor activation of innate immunity in fruit fly and mammals, respectively. Ralph M. Steinman received the award for the d...

Ralph M. Steinman, professor of immunology at The Rockefeller University in New York and one of the great immunologists of our time, died on September 30 after a long fight with pancreatic cancer, just three days before the announcement that he had been awarded the Nobel Prize in Physiology or Medicine for the discovery of the dendritic cell. Steinman is universally recognized for having given ...

Topical application of picryl chloride (PCL), 1 the chemically reactive form of the tr initrophenyl (TNP) hapten, regularly induces a contact hypersensitivity reaction (CS) that is of the long-lived type (>3 wk) (1). However, when T N P is coupled to cells in vitro and these cells are used for immunizat ion, three different immunological outcomes m a y ensue depending on the route of administra...

This issue of the Journal of Experimental Medicine celebrates and honors the life of Ralph Steinman (1943-2011), winner of the 2011 Nobel Prize in Physiology or Medicine. Ralph's science was rooted in fundamental discovery with the goal of translating these findings into clinical medicine. He recognized the power of immunology in treating human disease and passionately championed studies on vac...

DC are key regulators of immunity in view of the fact that they are involved in immune re‐ sponses against infectious diseases, allergy and cancer [1, 2]. Ralph Steinman was awarded the Nobel Prize for Medicine 2011 for DC discovery in 1973 [3]. Steinman and Cohn [3] de‐ scribed a novel cell type in mouse spleen, which they named ́dendritic cell ́ due to their tree-like shape. The major function ...

Osteoid osteoma is a benign, small but very painful bone tumour. The treatment consists of excision / destruction of nidus. In the past, conventional open excision of nidus was the usual treatment but now a days various other techniques have been described e.g. Percutaneous drilling , laser photocoagulation, chemical destruction or radio frequency ablation. These techniques have more predictabl...

On October 3rd of this year, we were excited to hear the news that Ralph M. Steinman had received the Nobel Prize in Medicine for his discovery of dendritic cells and their role in adaptive immunity. However, we were immediately in profound shock and grief by the news that he had passed away three days earlier from pancreatic cancer, which had troubled him for 4 years. The committee decided not...

We report a case of a 27-year-old man who was involved in a high-speed car accident. He sustained multiple organ damage including multiple brain petechiae suggesting diffuse axonal damage, aortic dissection, retroperitoneal haematoma and a fracture-dislocation of the right hip with a femoral head fracture and an ipsilateral intertrochanteric fracture. Due to the general condition of the patient...