Quiescence conserves the properties of stem cells whilst they are dormant. The mechanisms associated with dormancy involve various cell regulators. Here, the effects of hyaluronan (HA; a polysaccharide associated with the extracellular matrix), on the mesenchymal stem cell cycle and the involvement of p130 and E2F family proteins in mesenchymal stem cell cycle regulation, were evaluated. Placen...

Stem cells are unique that have the ability to differentiate into with specific functions and renew themselves produce new stem cells. One type of actively studied is Spermatogonial Cells (SSC). SSC a unipotent cell develops spermatozoa in mammalian testis. can be transplanted male testis recipients improve genetic quality livestock propagate valuable livestock. transplantation procedure starte...

The use of stem cells is a breakthrough in medical biotechnology which brings regenerative therapy into new era. Over the past several decades, had been widely used as and Mesenchymal Stem Cells (MSCs) emerged promising therapeutic option. Currently are effective agents againts diseases due to their tissue protective repair mechanisms. This effect largely biomolecular properties including secre...

Spermatogonial Stem Cell (SSC) technologies provide multiple opportunities for research in the field of biotechnology and regenerative medicine. The therapeutic use of Embryonic Stem Cells (ESCs) is restricted due to severe ethical and immunological concerns. Therefore, we need a new pluripotent cell type. Despite well-known role of germ cells in the gametogenesis, some facts apparently show th...

in this study, our aim was to produce a generation of gmp-grade adipose tissue-derived mesenchymal stem cells for clinical applications. according to our results, we fulfill to establish consistent and also reproducible current good manufacturing practice (cgmp) compliant adipose tissue-derived mesenchymal stem cells from five female donors. the isolated cells were cultured in dmem supplemented...

This project had led, thus far, to the development of four academic papers. The first of these was published in Nature Biotechnology and the second was published in Cell Stem Cell. The third paper has recently been submitted to a peer-reviewed journal, while the fourth is currently being revised in preparation for submission to a peer-reviewed journal later in the year. In addition, this projec...

Significant inequalities in health between and within countries have been measured over the past decades. Although these inequalities, as well as attempts to improve sub-standard health, raise profound issues of social justice and the right to health, those working in the field of bioethics have historically tended to devote greater attention to ethical issues raised by new, cutting-edge biotec...

Recent advances in genomics and biotechnology have ushered in a new era in health development. Therapeutic cloning possesses enormous potential for revolutionizing medical and therapeutic techniques. Cloning technology, however, is perceived as having the potential for reproductive cloning, which raises serious ethical and moral concerns. It is important that the Islamic countries come to a con...

introduction: hyperplastic pulpitis (pulp polyp)tissues contains cells with stem cell properties similar to that of the dental pulp stem cells (dpscs). it has also been shown that cd146 enrichment can homogenize the cultures of dpscs and enhance the colony forming potentials of their cultures. this study determines whether cd146 enrichment can help purifying the stem cells from heterogeneous cu...

purpose: to describe a novel surgical technique for in vivo limbal stem cell cultivation for reconstruction of corneal epithelium in total limbal stem cell deficiency (lscd). methods: patients suffering from chronic total unilateral lscd due to a chemical injury were sequentially included. one small limbal block (2x1 mm) harvested from contralateral healthy eye sutured over the amniotic membran...