The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation. Treatment cells with AZD2858 stimulates pathway, yet function this in remains unclear. Here, we found that promotes accumulation β-catenin nuclei stem from apical papilla (SCAPs) and enhances cell proliferation. Single-cell sequencing was performed on SCAPs treated AZD2858. Eight clusters were identified, n...

In the last decades, term stem cells has been one of main topics to be discussed due its scientific and medical importance, since implementation in field medicine offers us very promising alternatives treatment above all solution diseases such as diabetes, Alzheimer, Parkinson's disease, cancer, treatments traumatology orthopedics, transplants, oral surgery, well reconstruction organs tissues i...

Advances have been made in identifying dental stem cells and their differentiation potential. Five different types of dental stem cells have been isolated from dental soft tissues: dental pulp, apical papilla, dental follicle and periodontal ligament. The characteristic features of these cells have been explored. They express various arrays of biomarkers including those specific for mesenchymal...

Engineering of craniofacial tissues would have a profound impact on various treatment strategies in dentistry. The role of mesenchymal stem cells in the formation of all craniofacial and dental structures has been well demonstrated. Stem cells from various craniofacial structures like dental epithelium, dental follicle, apical papilla, exfoliated deciduous teeth, periodontal ligament and dental...