In a search for an indirect estimate of severity, data from 40 patients with pure aortic stenosis have been analyzed. Calculated aortic valvular areas ranged from 0.5 cm2 to 2.4 cm.2 Both aortic systolic upstroke time and the rate of aortic pressure rise were significantly altered by aortic stenosis; neither permitted reliable estimates of severity of the stenosis. An estimate of arterial compl...

BACKGROUND It is unclear whether coronary artery stenosis affects the secretion of N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) from the heart independent of ventricular dysfunction. Therefore, this study evaluated the relationship between BNP and NT-proBNP secretion, plasma levels and the severity of coronary artery stenosis in patients with stable c...

In the American Heart Association–American College of Cardiology and European Society of Cardiology–European Association for Cardio-Thoracic Surgery guidelines, aortic valve replacement (AVR) is considered a class I indication in patients with aortic stenosis (AS) if the stenosis is severe and the patient has symptoms or left ventricular ejection fraction <50%. Hence, accurate assessment of the...

BACKGROUND Myocardial fractional flow reserve (FFR) is based on pressure measurements. We have now sought to establish a Doppler-based concept of relative flow velocity reserve (RFVR) for the functional assessment of stenosis severity in epicardial coronary arteries. A clear threshold value to discriminate the functional severity of a coronary stenosis does not exist for coronary flow velocity ...

 Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol.  Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during...

OBJECTIVES The purpose of this study was to assess the long-term results of endoscopic dilatation of airway stenosis and to evaluate predictive factors for favorable results. METHODS Fifty-four patients with tracheal and subglottic stenosis who underwent endoscopic dilatation with at least 12 months follow-up were enrolled in this study. We evaluated predictive factors for final treatment out...

OBJECTIVE To determine whether the effectiveness of core stability exercises correlates with the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis. METHODS Forty-two patients with degenerative lumbar spinal stenosis treated in the department of orthopedics of our hospital between May 2013 and January 2016 were included in the study. All the patients performed co...

AIMS Coronary plaque characteristics are associated with ischaemia. Differences in plaque volumes and composition may explain the discordance between coronary stenosis severity and ischaemia. We evaluated the association between coronary stenosis severity, plaque characteristics, coronary computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT), and lesion-specific ischaemi...

We describe a novel method for assessing stenosis severity based on pressure wave measurements. Pressure waves for several degrees of stenosis at different distances proximal to the stenosis were recorded from in vitro and in vivo models. Signal analysis was performed using power spectral density, and radial compliance was also measured. Pressure wave components at the acoustic frequency band (...

Fifteen years ago, Topol and Nissen1 described the oculostenotic reflex as an “irresistible temptation ... to perform angioplasty on any significant residual stenosis,” highlighting a widely held misperception that an angiographically severe stenosis must cause ischemia and that revascularization results in clinical benefit. Although quantitative angiography improves the accuracy of stenosis se...