Stereotactic body radiation therapy constitutes an emerging therapeutic paradigm. These treatments are unique relative to the large body of experience with conventional fractionated radiotherapy. On the basis of the treatment principles of intracranial stereotactic radiation combined with enhancements associated with immobilization and imaging, the role of extracranial treatment continues to ev...

Fifty-one patients with supratentorial glioma treated with external beam radiotherapy (median dose 59.5 Gy) who then demonstrated clinical or radiographic evidence of disease progression underwent stereotactic biopsy to differentiate tumor recurrence from radiation necrosis. The original tumor histological type was diffuse or fibrillary astrocytoma in 21 patients (41%), oligodendroglioma in 13 ...

Song and colleagues deliver a thorough and fair review of the initial clinical investigations of a new paradigm in radiotherapy most recently called stereotactic body radiation therapy (SBRT).[1] Oncology observers may take exception with the use of the designation “new paradigm.” After all, from a tumor control point of view, skeptics might say, “radiotherapy is radiotherapy.” Recent advances ...

PURPOSE To characterize the effect of the relative motion of esophagus and tumor on radiation doses to the esophagus in patients treated with stereotactic body radiation therapy for central lung tumors. METHODS AND MATERIALS Fifty fractions of stereotactic body radiation therapy in 10 patients with lung tumors within 2.5 cm of the esophagus were reviewed. The esophagus was delineated on each ...

The management of pancreatic cancer continues to be challenging. Despite surgical, genetic and molecular advances, its overall prognosis remains poor. Surgical resection is the only modality that offers a chance for a cure, with an overall survival rate of 10-20% at 5 years. However, only 20% of the patients are surgical candidates because of locally advanced disease or systemic stage at presen...

Fig. 1. Tumor control probability (TCP) versus biologically effective dose (BED) using the linear quadratic (LQ) model. Data are from Mehta et al (3). The fitted line was obtained using a logistic regression model. The vertical lines indicate the 95% confidence intervals for each cohort. Three-dimensional conformal radiation therapy (3D-CRT; >10 fractions), stereotactic body radiation therapy (...

Background Intensity-modulated stereotactic radiotherapy achieves improvements in the ability to produce conformal stereotactic dose distributions by modulation of the intensity of individually delivered beamlets of radiation. Image-guided intensity-modulated stereotactic radiotherapy has emerged as a new treatment option in the multidisciplinary management of metastatic and locally advanced ca...

The uptake of stereotactic ablative body radiation therapy (SABR)/stereotactic body radiation therapy (SBRT) worldwide has been rapid. The Australian and New Zealand Faculty of Radiation Oncology (FRO) assembled an expert panel of radiation oncologists, radiation oncology medical physicists and radiation therapists to establish guidelines for safe practice of SABR. Draft guidelines were reviewe...

Radiation treatment in the management of pituitary adenoma in children is still a controversy due to the great concern of late radiation effect. Stereotactic radiation therapy is the modern radiation technique that is more widely applicable in pituitary adenoma because of the ability to give highly conformal radiation to the target organ and to reduce the radiation dose to normal tissue. A 15-y...