In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p

Ibuprofen, a widely used non-steroidal anti-inflammatory, anti-pyritic and analgesic, occurs in the aquatic systems of 47 countries. It was removed (∼70 mg g −1 Langmuir ∼30 at 7.5 L by column uptake) <40% activated carbon’s cost.

A convergent synthesis of a novel estrogen receptor-targeted drug hybrid was developed based on structures of the potent anti-proliferative mitomycin C and the steroidal anti-estrogen RU 39411. The steroidal antiestrogen was prepared with an azido-triethylene glycoloxy linker while the mitomycin C derivative (porfirimycin) incorporated a complementary 7-N-terminal alkyne. The two components wer...

Background: This study aimed to evaluate the prescription patterns and safety profiles of oral non-steroidal anti-inflammatory drugs (NSAIDs) in three Chinese hospitals.

A workshop, "Chemopreventive properties of nonsteroidal anti-inflammatory drugs (NSAIDs): Role of COX-dependent and -independent mechanisms," sponsored by the Chemical and Physical Carcinogenesis Branch, Division of Cancer Biology of the National Cancer Institute, was held in Rockville, Maryland, on January 8, 2001. The workshop was composed of two parts: oral presentations by a series of speak...