background & aim: spinal cord injury (sci) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities.  methods & materials/patients: in this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (g-csf) and...

Human granulocyte colony stimulating factor (hG-CSF) induces proliferation and differentiation of granulocyte progenitor cells. This glycoprotein is currently being used for treatment of neutropenia, in patients who have undergone bone marrow transplantation. So far, different researchers have tried to enhance hG-CSF biological activity and stability. In this study, Polymerase Chain Reaction (P...

we present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. treatment with granulocyte colony-stimulating factor (g-csf) r...

Introduction This study was designed to identify the set of functions activated in cultured endothelial cells by the hematopoietic growth factors, granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage-colony-stimulating factor (GMCSF), and to compare them with those elicited by prototypic cytokines active on these cells. Moreover, indications as to the in vivo relevance of in...

The role of alveolar macrophages in the production of granulocyte/ macrophage colony-stimulating factor(s) by the rat lung was investigated. Lavaged lungs, when incubated at proper weight per volume of culture medium, produced the same amount of colony-stimulating factor as unlavaged ones. Both lavaged and unlavaged lungs produced similar types of colony-stimulating factor (s). Prolonged i...

17. Morstyn G, Campbell L, Lieschke G, et al. Treatment of chemotherapy induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and durationof therapy.3 Clin Oncoll989,7,1554-1562. Brugger W, Bross KJ, Lindemann A, Kanz L, Mertelsmann M. Role of hematopoietic growth factor combinations in experimental and clinical oncology. Semin Oncoll...