3.1. Overview 2807 3.2. Chiral Aluminum(III) Complexes as a Catalyst 2808 3.2.1. Aluminum(III)-Salen-Based Catalysts 2808 3.2.2. Aluminum(III)-Binaphthol-Based Catalysts 2810 3.3. Chiral Titanium(IV) Complexes as a Catalyst 2814 3.3.1. Titanium(IV)-Peptide-Based Catalysts 2814 3.3.2. Titanium(IV)-Diol-Based Catalysts 2817 3.4. Chiral Zirconium(IV) Complexes as a Catalyst 2818 3.4.1. The Catalyt...

A range of 3H-indoles and 2H-benzo[b][1,4]thiazines smoothly undergo asymmetric Strecker reaction with ethyl cyanoformate in the presence of a Cinchona alkaloid-based thiourea catalyst at 10 °C to give structurally diverse nitrogen-containing heterocycles in good to excellent yields and with excellent ee.

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.

S. Zwick, R. Strecker, M. Palmowski, P. Gall, V. Kiselev, A. Hengerer, W. Semmler, and F. Kiessling Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, HealthCare Sector, Siemens AG, Erlangen, Germany, Department of Experimental Molecular Imaging, RWTH-Aachen University, Aachen, Germany, Department of Diagnostic Radiology, University Hospital Freiburg, Freiburg, Ge...

Recently it has been demonstrated that the typical aroma of oxidative spoiled white wine are related with the presence of methional and phenylacetaldehyde, substances accountable respectively for the “boiled-potato” and “honey-like” odour notes with threshold values of 0.5 μg/L and 25 μg/L . These compounds can be formed by the direct oxidation of the respective alcohol or via Strecker degradat...

an efficient, mild and environmentally friendly method was developed for the strecker reaction to synthesize α-aminonitriles in the presence of methyl imidazolium hydrogen sulfate ([hmim][hso4]) as an efficient catalyst. these syntheses were performed via a one-pot three-component condensation of aldehydes (or ketones), amines, and trimethylsilyl cyanide under mild and solvent free conditions.

a simple and efficient one-pot, three-component strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. the reaction was carried out in the presence of catalytic amount of phosphotungstic acid (h3[p(w3o10)4]) as an environmentally friendly catalyst.

We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.