The objective of the present study was to evaluate the antihyperglycemic activity of methanolic extract of Trianthema portulacastrum whole plant in streptozotocin-induced diabetic rats. The STZ induced diabetic rats are divided into four groups of six animals each. Group I served as diabetic control, Group II diabetic rats were treated with a standard oral hypoglycaemic agent, glibenclamide (1m...

Coccinia indica leaves were extracted with 60 % ethanol, solvents were evaporated and the residue was suspended in water. This suspension was administered orally at a dose of 200 mg/kg body wt. after 18 h of fasting to normal fed and streptozotocininduced male diabetic rats (180-250 g). After 90 min the rats were killed, and blood-glucose, hepatic glucose-6-phosphatase, fructose-1,6-bisphosphat...

The liver is a key player in glucose regulation, and several factors are involved in this regulation (1). Glucagon, autonomic nerves, and the adrenals stimulate hepatic glucose production to allow sufficient brain glucose delivery. Insulin inhibits hepatic glucose production, preventing excess hepatic glucose release. This is of particular importance after meals, as is evident from the negative...

adipocyte fatty acid-binding protein Contribution of serum adipocyte fatty acid-binding protein levels to the presence of microalbuminuria in a Chinese hyperglycemic population, Hu 582–589 adult-onset autoimmune diabetes Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes, Lu 619–625 advanced glycation end-products Advanced glycation end-products are a ...

DIABETES IS AN EPIDEMIC in the United States, affecting 8% of the population. The hallmark of diabetes is hyperglycemia due to either insulin deficiency or insulin resistance. Systemic vascular dysfunction is a central part of the pathophysiology of both type I insulin-dependent and type II non-insulin-dependent diabetes and involves both the microand macrocirculation (11). Coronary heart disea...