A large and growing literature suggests that traumatic experiences early in life increase the risk of mood and anxiety disorders in genetically predisposed persons. Findings from laboratory animal studies as well as studies of women with histories of early-life trauma demonstrate that long-lived alterations in the corticotropin-releasing factor (CRF) system and stress responses underlie this vu...

Abstract. We address, in this chapter, the identification of typical patterns that best characterize a set of sequences. More specifically, we focus on data-driven methods that search for the typical patterns among the observed sequences. In life course studies, such typical sequences serve, for instance, to describe ideal-type life trajectories; i.e., the common way(s) of organizing our life. ...

We show how the quantum-to-classical transition of the cosmological fluctuations produced during an inflationary stage can be described using the consistent histories approach. We identify the corresponding histories in the limit of infinite squeezing. To take the decaying mode into account, we propose an extension to coarse-grained histories. PACS Numbers: 04.62.+v, 98.80.Cq

Three techniques for measuring dynamic stress intensity factor time histories of dynamically loaded stationary modeI cracks are compared as applied to dynamically loaded pre-cracked 6Al–4V titanium alloy specimens. The three techniques are crack opening displacement (COD), dynamic strain gage measurement, and coherent gradient sensing (CGS). The stress intensity factor histories are inferred fr...

The predictions of the Bohmian and the decoherent (or consistent) histories formulations of the quantum mechanics of a closed system are compared for histories — sequences of alternatives at a series of times. For certain kinds of histories, Bohmian mechanics and decoherent histories may both be formulated in the same mathematical framework within which they can be compared. In that framework, ...

Allostatic load (AL) is the cumulative physiological "cost" of prolonged stress. An AL composite measure successfully predicts morbidity and mortality among the elderly but has not been reported in "high stress" samples with posttraumatic stress disorder (PTSD). Accordingly, AL was measured in mothers (ages 29-55) of pediatric cancer survivors and control mothers of healthy children. A signific...

OBJECTIVES To evaluate whether cue-evoked affective response would moderate the relationship between depression-proneness and smoking years. METHODS Depression-proneness profiles were derived using clinician diagnosed personal and family histories of major depression, recurrent depression, trait-anhedonia, and ruminative coping styles (n=70). Affective distress was produced by idiographic, gu...

Metabolic flexibility is an important component of adaptation to stressful environments, including thermal stress and latitudinal adaptation. A long history of population genetic studies suggest that selection on core metabolic enzymes may shape life histories by altering metabolic flux. However, the direct relationship between selection on thermal stress hardiness and metabolic flux has not pr...

This paper presents a new method to correct for measurement error in wage data and applies this method to address an old question. How much downward wage flexibility is there in the U.S? We apply standard methods developed by Bai and Perron (1998b) to identify structural breaks in time series data. Applying these methods to wage histories allows us to identify when each person experienced a cha...