BACKGROUND For stage I-II colon cancer a significant number (5-25%) of patients has recurrent disease within 5 years. There is need to identify these high-risk patients as they might benefit from additional treatment. Stroma-tissue surrounding the cancer cells plays an important role in the tumor behavior. The proportion of intra-tumor stroma was evaluated for the identification of high-risk pa...

  Introduction: The process of discriminating among benign and malignant hyperplasia begun with subjective methods using light microscopy and is now being continued with computerized morphometrical analysis requiring some features. One of the main features called Volume Percentage of Stroma (VPS) is obtained by calculating the percentage of stroma texture. Currently, this feature is calculated ...

PURPOSE Generation of a reactive stroma environment occurs in many human cancers and is likely to promote tumorigenesis. However, reactive stroma in human prostate cancer has not been defined. We examined stromal cell phenotype and expression of extracellular matrix components in an effort to define the reactive stroma environment and to determine its ontogeny during prostate cancer progression...

The stroma is a relevant player in driving and supporting the progression of pancreatic ductal adenocarcinoma (PDAC), large body evidence highlights its role hindering efficacy current therapies. In fact, dense extracellular matrix (ECM) characterizing this tumor acts as natural physical barrier, impairing drug penetration. Consequently, all approaches combining stroma-targeting anticancer ther...

The color of human eyes is often the same as iris eye, which itself consists two parts: anterior layer stroma and posterior or pigment epithelium. Based on experiments, it believed that determined based four factors: granules in epithelium, concentration stromal melanocytes, melanin pigments scattering absorption light from extracellular matrix properties stroma. Becomes. In general, melanocyte...

Background: The aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. Methods: Human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. Full thickness of human normal endometrial sections and cultured endometrial cells ...

To investigate the mechanism of superficial stromal scarring in advanced keratoconus using confocal microscopy, the keratocyte density, distribution, micromorphology of corneal stroma, and SNP in three groups were observed. Eight corneal buttons of advanced keratoconus were examined by immunohistochemistry. The keratocyte densities in the sub-Bowman's stroma, anterior stroma, and posterior stro...

PURPOSE To isolate multipotent precursors from the rabbit corneal stroma and to compare the distribution and proliferative capacity of keratocyte precursors obtained from the central and peripheral regions of the corneal stroma. METHODS The rabbit corneal stroma was divided into a peripheral region (6.0-10.0 mm in diameter) and a central region (6.0 mm in diameter). A sphere-forming assay was...

tumors that originate from the nerve sheath comprise diverse groups -perineuroma, neurofibroma and schwannoma. the epithelioid variant of these tumors is uncommon and mostly seen in malignant counterparts. although this type of morphology is well recognized in peripheral nerve sheath tumors, its presence in the central nerves is rarely reported. very few cases of nerve sheath tumors have been r...

OBJECTIVE Tumor-stroma ratio (TSR) has been identified as a new and practicable prognostic histological characteristic of solid tumors. The aim of this study was to evaluate the prognostic value of TSR in resected esophageal squamous cell carcinoma (ESCC). METHODS A total of 95 patients who underwent esophagectomy for ESCC were included in this study. TSR was assessed visually on the hematoxy...