Since the publication of Shannon’s theory of one terminal source coding, a number of interesting extensions have been derived by researchers such as Slepian-Wolf, Wyner, Ahlswede-Körner, Wyner-Ziv, Berger et al. and Berger-Yeung. Specifically, the achievable rate or rate-distortion region has been described by a first order information-theoretic functional of the source statistics in each of th...

At several recent conferences, the question “What is Structural Complexity Theory?” has been the source of some lively discussions. At this time there does not exist one commonly accepted answer but the intersection of almost all answers is nonempty. The purpose of this paper is to describe one answer to this question. We will not describe in detail recent technical results, although some will ...

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The different kinds of communication links that can exist in an interaction among objects pose the question of whether every link is or is not an instance of an association, and whether an association must exist whenever there is a communication path between objects. The distinction between static and dynamic associations is not adequate to solve this problem, since in object-orientation every ...

Two directed evolution experiments on p-nitrobenzyl esterase yielded one enzyme with a 100-fold increased activity in aqueous-organic solvents and another with a 17 degrees C increase in thermostability. Structures of the wild type and its organophilic and thermophilic counterparts are presented at resolutions of 1.5 A, 1.6 A, and 2.0 A, respectively. These structures identify groups of interac...

It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity. We hypothesize that the correct identification of the pairing should take into account the effect of the Argonaute protein (AGO), an essential catalyst of the recognition process. Therefore, we develo...