Cardiovascular diseases (CVD) are nowadays real health problems in the world. High blood pressure is one of most important risk factors for CVD and affecting more people Benin. The objective our work to evaluate safety efficacy leaves five plants used treatment hypertension Acute toxicity was evaluated on wistar rats which orally administered a single dose 2000 mg/kg body weight hydro-ethanolic...

The acute and subacute toxicity profile of the aerial extract of Monsonia angustifolia in Wistar rats was evaluated. The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with a single oral dose of 5000 mg/kg (b.w.). For the 28-day daily oral dosing, the extract was administered at 75, 150, and 300 mg/kg b.w.; 1% ethanol in ster...

Introduction S1 Pharmacological actions S2 Traumatic lesions and experimental cerebral oedema S2 Cerebral hypoxia and ischaemia S5 Synaptic transmission and neurotransmitter levels S13 Learning performance, memory and brain ageing S17 Experimental withdrawal syndrome and intoxications S19 Toxicity S20 Acute toxicity S20 Subacute toxicity S20 Chronic toxicity S20 Teratogenicity S20 Pharmacokinet...