Subarachnoid injection of alcohol for the relief of intractable pain was introduced by Dogliotti (1, 2 ) before the .Academy of Medicine of Turin in December 1930. He was induced to try it in the belief that to suppress pain surgically it was not necessary to destroy all the sensory fibers but to reduce the number and intensity of stimuli sufficiently so that they would not register as pain. Th...

We read with much interest the case report titled 'Cardiopulmonary Arrest Following Cervical Epidural Steroid Injection' by Stauber et al (1) in the March/April 2012 issue. The case report highlighted a cardiopulmonary arrest which occurred within 5 seconds after the injection of epidural steroid in 1% lidocaine. The quoted amount of betamethasone was 12 mg in a total volume of 4 mL. Assuming a...

Introduction: Coenzyme Q10 is a powerful antioxidant that has the ability to reduce the damage caused by oxidative stress and is predominantly found in the inner mitochondrial membrane. This study was conducted to determine the effect of coenzyme Q10 on neuropathic pain in an animal model of spinal cord injury. Methods: In order to induce neuropathic pain, thoracic segments of the spinal cor...

BACKGROUND AND OBJECTIVES Combined spinal epidural anesthesia (CSEA) has advantages over single injection epidural or subarachnoid blockades. The objective of this report was to present a case in which segmental subarachnoid block can be an effective technique for gastrointestinal surgery with spontaneous respiration. CASE REPORT Patient with physical status ASA III, with diabetes mellitus ty...

background developing controlled hypercarbia is a known scheme of lowering the suprasellar part of the adenoma in order to assist the surgeon, which acts through raising the icp and therefore the csf pressure. objectives the purpose of this study is to compare the effect of introducing a lumbar drain with that of controlled hypercapnia on the quality of transsphenoidal pituitary tumor resection...

BACKGROUND AND OBJECTIVES Lumbar epidural blood patch (EBP) is a commonly used procedure to treat postdural puncture headache. We present a case of vision loss immediately following an EBP. CASE REPORT A 49-year-old woman with idiopathic intracranial hypertension received an EBP for postdural puncture headache at an outside facility without fluoroscopic guidance and in the seated position. Th...

An association between intercostal nerve block and the development of a total spinal is rare. Usually, subarachnoid injection is considered to have followed intraneural placement or inadvertent entrance into a dural cuff extending beyond an intervertebral foramen. We report a patient that followed injection of local anaesthetic into a paravertebral catheter sited at surgery in the thoracic para...

Acute traumatic brain injury is a worldwide public health crisis. Post-traumatic subarachnoid hemorrhage (SAH) is a finding that is present at a frequency of 40% according to data from American TCDB (1,2). Among the mechanisms that have been implicated as causes of post-traumatic SAH is the cortical bleeding through the subarachnoid space. It is estimated that the incidence of post-traumatic SA...

Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarachnoid blood injection, is presumed to occur because of the platelet inhibiting...

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a larger dose continuously injected over a longer period. The subarachnoid space is modeled as an annular gap of constant or slowly varying cr...