Objectives—Intraventricular astrocytomas (subependymal giant cell astrocytomas) of tuberous sclerosis have a poor prognosis due to the obstruction of CSF flow. The aim of this study was to determine whether they could be diVerentiated during childhood and at an early preclinical stage, from subependymal nodules without any growing potential. Methods—The first two MRIs of all children referred t...

Five young infants with congenital rubella syndrome (CRS) underwent cranial ultrasonographic examinations and/or computed tomographic examinations. Only two of these infants were small for their gestational age, and none of them were microcephalic at birth. Deafness and ocular lesions were found in four patients, and congenital heart disease was found in three. All had abnormal ultrasonographic...

OBJECTIVES Intraventricular astrocytomas (subependymal giant cell astrocytomas) of tuberous sclerosis have a poor prognosis due to the obstruction of CSF flow. The aim of this study was to determine whether they could be differentiated during childhood and at an early preclinical stage, from subependymal nodules without any growing potential. METHODS The first two MRIs of all children referre...

Answer: C A 63-year-old Chinese hawker presented with episodic left-sided dull abdominal pain over several years, associated with increasing abdominal distention and early satiety. She also had very occasional dyspnoea. Physical examination revealed bilateral ballotable renal masses. A slightly raised fi brous plaque was noted on the left side of her forehead. Her full blood count, renal panel,...

BACKGROUND AND PURPOSE Subependymal enhancement and DWI have been reported to be useful MR imaging markers for identifying true progression. Our aim was to determine whether the subependymal enhancement pattern and ADC can differentiate true progression from pseudoprogression in patients with glioblastoma multiforme treated with concurrent chemoradiotherapy by using temozolomide. MATERIALS AN...

PURPOSE To determine the value of inversion recovery half-Fourier single-shot turbo spin-echo (IR-HASTE) MR sequences in the characterization of a variety of intracranial lesions, with the focus on differentiating between epidermoids and nonneoplastic cystic lesions. METHODS We used a 1.5-T MR unit to study five epidermoids, seven arachnoid cysts, seven other nonneoplastic cysts (three neuroe...

Neurogenesis from endogenous progenitor cells in the adult forebrain ventricular wall may be induced by the local viral overexpression of cognate neuronal differentiation agents, in particular BDNF. Here, we show that the overexpression of noggin, by acting to inhibit glial differentiation by subependymal progenitor cells, can potentiate adenoviral BDNF-mediated recruitment of new neurons to th...

Tuberous sclerosis complex Syndrome (TSCs) is an autosomal dominant disorder affecting multiple organs; caused by mutations of either the TSC1 or TSC2 gene encoding hamartin and tuberin respectively. It is characterized by the development of benign tumours affecting different body systems. The most common visible manifestations of TSC are facial angiofibromas and the formation of hamartomas in ...

BACKGROUND AND PURPOSE Subependymal grey matter heterotopias are seen in a high proportion of children with Chiari II malformation and are potentially clinically relevant. However, despite its growing use, there is little in the literature describing its detection on fetal MRI. Our aim was to evaluate the accuracy in diagnosing subependymal gray matter heterotopias in fetuses with spinal dysrap...