IMPORTANCE Allergic rhinitis affects up to 40% of the US population. To desensitize allergic individuals, subcutaneous injection immunotherapy or sublingual immunotherapy may be administered. In the United States, sublingual immunotherapy is not approved by the Food and Drug Administration. However, some US physicians use aqueous allergens, off-label, for sublingual desensitization. OBJECTIVE...

Sublingual Vaccines In article number 2102508 by Mariana Landin and co-workers, an optimized hydrogel is developed using artificial intelligence for sublingual delivery of the Chlamydia subunit vaccine CTH522, following parenteral immunization with this included in CAF01 liposomes. This strategy promotes Th1&Th17 immune responses elicits a local IgA response genital tract. Cover made Leticia Go...

BACKGROUND Sublingual varices have earlier been related to ageing, smoking and cardiovascular disease. The aim of this study was to investigate whether sublingual varices are related to presence of hypertension. METHODS In an observational clinical study among 431 dental patients tongue status and blood pressure were documented. Digital photographs of the lateral borders of the tongue for gra...

INTRODUCTION The aim of the study was to evaluate and compare the microcirculatory perfusion during experimental sepsis in different potentially available parts of the body, such as sublingual mucosa, conjunctiva of the eye, and mucosa of jejunum and rectum. METHODS Pigs were randomly assigned to sepsis (n = 9) and sham (n = 4) groups. The sepsis group received a fixed dose of live Escherichi...

This is a review of the author's experience with Sublingual Immunotherapy in a private office setting. Sublingual Immunotherapy should be considered by any allergy practitioner as a useful tool. Sublingual Immunotherapy is safe while at the same time it is effective. It enables the practitioner to treat asthmatics and young children without the concerns implicit with allergy injections.

Sublingual immunization, where the vaccine is placed directly under the tongue and absorbed through the sublingual mucosa, has the advantages of ease of delivery without the complication of oral administration or the safety concerns of intranasal vaccines. Sublingual vaccine delivery has been shown to induce development of humoral and cell mediated immunity in both the systemic and mucosal comp...

Background: Labor induction is one of the most public ways carried out global for delivering mothers. The aim of labor induction is to encourage uterine contractions before the spontaneous onset of labor, resultant in vaginal delivery misoprostol is used off-label for a variety of indications in the practice of obstetrics and gynecology, including medication abortion, medical management of misc...

BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...

Ranulas are cystic lesions which results from rupture or damage of ducts of the sublingual glands leading to mucus extravasation or dilatation of the gland's duct. Extravasation cysts are more common as compared to retention cysts. Ranula mostly arises from sublingual glands and involvement of the submandibular gland is rare. Ranula often protrudes into the floor of the mouth, having only an or...

Submit Manuscript | http://medcraveonline.com J Anesth Crit Care Open Access 2015, 3(2): 00085 of first pass metabolism so it provides better bioavailability. It is a non invasive and painless route of administration. It is also suitable for patients with nausea, vomiting, dysphagia, gastrointestinal disturbance such as obstruction. The systemic drug delivery after sublingual route is fast as d...