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OBJECTIVES Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. MATERIALS AND METHODS BALB/c...

BACKGROUND Compliance with prescribed treatment is essential for reducing costs of health care and improving efficacy of treatment in patients with allergic rhinitis. OBJECTIVE To evaluate the extent of compliance and identify predictive factors and risk profiles for patient noncompliance with the therapeutic regiments of sublingual immunotherapy and H1-antihistamines. METHODS In this retro...

BACKGROUND Sublingual administration of allergens is a safe and effective alternative to subcutaneous immunotherapy in patients with respiratory allergies. A drawback to this therapeutic approach is the relatively long and complex management of the induction phase. AIM OF THE STUDY To determine whether different induction regimens affect the outcome of sublingual immunotherapy. METHODS AND ...

Allergic rhinitis is the most prevalent type I allergy in industrialized countries. Pollen scattering from trees or grasses often induces seasonal allergic rhinitis, which is known as pollinosis or hay fever. The causative pollen differs across different areas and times of the year. Impaired performance due to pollinosis and/or medication used for treating pollinosis is considered to be an impo...

The purpose of this review is to highlight recently published important articles on upper airway diseases and immunotherapy. We review articles on rhinitis, sinusitis, conjunctivitis, and immunotherapy. New insights into epidemiology, pathophysiology, diagnosis, and therapy are described for each of the above diseases. Regarding immunotherapy, we discuss numerous clinical trials on sublingual a...