Three test-plot series have been performed to gather information on runoff of sulfonamides from manured arable and grassland after sprinkler irrigation. To prepare test slurries with defined aged residues, liquid bovine manure was fortified with sulfadiazine, sulfadimidine, and sulfamethoxazole and stored short-term. After test-slurry application, the arable land was treated by soil cultivation...

Parasitism in food animal is of great economic importance. Coccidiosis is one of the gastrointestinal parasites that have a high detrimental effect on the sheep industry. A two and a half year-old ram was brought from the northern part of Nigeria into the University Teaching and Research Farm, Federal University of Agriculture, Abeokuta, Nigeria on the 30th December, 2010. About two weeks later...

Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane X receptor (PXR) reporter gene assay was established to screen CYP3A4 inducers. To evaluate results from the PXR reporter gene assay with those from the aforementioned conventional assays, 14 drugs wer...

The objective of this study was to evaluate and compare the effect of four superdisintegrants such as croscarmellose sodium (Ac-Di-Sol), crospovidone (Kollidon CL and with smaller particle sizes Kollidon CL-F), sodium starch glycolate (Explotab) in combination with β-lactose and microcrystalline cellulose (Avicel PH-102) as base excipients exhibiting properties of directly compressed tablets an...

1. Lincomycin is an antibiotic derived from Streptomyces lincolnensis. It belongs to the lincosamide group which also includes pirlimycin and clindamycin. In veterinary medicine, it is used in monopreparations and in combination product with other antibiotics such as spectinomycin, sulfadimidine and gentamicin. It is administered to poultry orally, sometimes in the feed or drinking water, at do...

The aim of this study was to determine whether antineoplastic cytostatic therapy induces changes in the oxidation or acetylation phenotypes in patients with acute myeloblastic leukemia (AML). The investigations involved 22 patients with AML undergoing chemotherapy with daunorubicin, cytosine arabinoside, etoposide and mitoxantrone. The oxidation phenotype prior to therapy and after termination ...

The occurrence and distribution of six typical antibiotics in the main rivers of Hong Kong were investigated using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ES-MS/MS). The results revealed that the antibiotics were widely distributed in the area studied. Of the target antibiotics, ofloxacin was the most frequently detected in the rivers, with ...

Article history: Received on: 25/11/2014 Revised on: 14/12/2014 Accepted on: 26/12/2014 Available online: 30/01/2015 A simple, robust and reliable reversed phase HPLC method was developed and validated for the simultaneous determination of Trimethoprim (TMP), Sulfadimidine sodium (SDMS) and Tylosin tartrate (TYT) in Nuroprim injectable solution formulation. The desired separation was achieved o...