BACKGROUND AND PURPOSE Pilot clinical trials using magnesium sulfate in patients with acute aneurysmal subarachnoid hemorrhage have reported trends toward improvement in clinical outcomes. This Phase III study aimed to compare intravenous magnesium sulfate infusion with saline placebo among such patients. METHODS We recruited patients with aneurysmal subarachnoid hemorrhage within 48 hours of...

conclusions intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. further larger studies are required. objectives this study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. patients and methods in a randomized double-blinded clinical trial, all patients ...

introduction: renal colic can be managed by preventing the contraction movements of ureter muscles. by reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. the aim of this study is to investigate the effect of magnesium sulfate on acute renal colic pain relief. method: the present study was a double-blind clinical trial in which the patients suffer...

Neurons in the adult CNS do not spontaneously regenerate after injuries. The glycosaminoglycan keratan sulfate is induced after spinal cord injury, but its biological significance is not well understood. Here we investigated the role of keratan sulfate in functional recovery after spinal cord injury, using mice deficient in N-acetylglucosamine 6-O-sulfotransferase-1 that lack 5D4-reactive kerat...

Objective: Magnesium sulfate has been shown to provide analgesia when administered into the knee joints. The aim of this study was to evaluate the histopathological effects of intraarticular administration of magnesium sulfate in the rat knee joint. Design: A total of 50 rats were given 0.25ml of magnesium sulfate (10%) by injection into the right knee joint and 0.25ml of 0.9% saline solution b...

The proteoglycans of the Rhesus monkey corneal stroma were characterized by analyzing both radiolabeled proteoglycans synthesized by corneas in organ culture and native corneal proteoglycans obtained by large scale preparations. The analyses indicate that the proteoglycans synthesized in organ culture were similar to, if not identical with, their counterparts in the stroma although they are syn...