p-Aminomethylbenzenesulphonamide (I) was first described by Miller, Sprague, Kissinger & McBurney (1940), and is used in therapy as its hydrochloride, Ambamide (formerly Marfanil). Its antibacterial properties were studied by Klartr (1941) who found it to be less active than sulphanilamide against streptococci, but more active against anaerobic bacteria (cf. Schoop & Stoltz, 1941 Hamre, Walker,...

The aim of the present study was to determine the in-vitro susceptibility of Toxoplasma gondii to dihydrofolate reductase inhibitors and sulphonamides alone, and in combination. It was found that pyrimethamine had the most potent anti-Toxoplasma activity, while sulphadiazine, sulphamethoxazole and sulphametrole were approximately equally effective, but only at a high concentration. The 50% inhi...

Ninety-three rectal swabs of lambs and young goats from two extensively and two intensively managed herds in Jordan were taken and examined for Shiga toxin-producing Escherichia coli (STEC). The bacteriological examination included the preenrichment of rectal swabs in EC broth with novobiocin, and a subsequent parallel isolation on enterohemolysin agar and immunomagnetic separation with cultiva...

Extensive experimental and clinical studies of the last five years have established the advantages of sulphonamide mixture therapy. 1-17 In brief the rationale for the use of mixtures is as follows: The renal toxicity of most of the newer sulphonamides, if used singly, is due primarily to over-saturation of the tubular urine with a sparingly soluble sulphonamide and/or its metabolic product, re...