Abstract Repulsive electrostatic forces between prion‐like proteins are a barrier against aggregation. In neuropharmacology, however, prion's net charge ( Z ) is not targeted parameter. Compounds that selectively boost prion remain unreported. Here, we synthesized compounds amplified the negative of misfolded superoxide dismutase‐1 (SOD1) by acetylating lysine‐NH 3 + in amyloid‐SOD1, without na...

Recent work has suggested that yes/no response formats, or active choice, can increase enrollment compared to opt-in procedures. To encourage even greater enrollment and increased participant engagement in academic research studies, we investigated the impact on participation rates of presenting multiple “yes” or “no” options. We demonstrate that the provision of additional, more labor-intensiv...

Several innovative random-sampling and random-mixing techniques for solving problems in linear algebra have been proposed in the last decade, but they have not yet made a significant impact on numerical linear algebra. We show that by using a high-quality implementation of one of these techniques, we obtain a solver that performs extremely well in the traditional yardsticks of numerical linear ...

Abstract High-pressure pulsed water jet technology has considerable development potential in the field of rock fragmentation. To overcome shortcomings existing jets, a self-supercharging (SSPWJ) generation method is proposed, which based on theory and principle hydraulic boosting. The proposed changes flow direction fluid medium through valve core to make piston reciprocate cylinder relies effe...

A non-linear gas dynamic model is used in this paper to study the pressure pulsations in the intake of a variable speed compressor, since the perturbation pressure in this study is so large that the linear acoustic theory is no longer valid. Friction and heat transfer are considered in the model. Three numerical schemes are applied to solve the governing equations which are non-linear hyperboli...

Protein aggregation, a well-known culprit in human disease,1,2 is also a major problem facing the use of proteins as therapeutic or diagnostic agents.3,4 Insights into the protein aggregation problem have been garnered from the study of natural proteins, where a relationship between solubility and net charge has been noted. For example, it is known that proteins are least soluble at their isoel...