Swelling agents are hydrophilic crosslinked polymers, which swell from 10 to 1,000 times their own weight when placed in an aqueous medium. Depending on their swelling properties, these materials have been exploited in developing three different classes of materials in pharmaceutical industries, i.e. swellable matrices, superdisintegrants and swelling devices. Since their development, these pha...

The present work aimed at preparing films of amlodipine with the reason of developing a dosage from for a very fast onset of action, which is beneficial in managing servere conditions of hypertension, aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water. Amlodipine is a calcium channel blocker that dilates (wi...

Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...

In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orodispersible tablets by using croscarmelloe sodiu...

Orally disintegrating tablets (ODTs) have become a rapidly growing area in the pharmaceutical industry during the last decade. Drugs exhibit the advantage of good absorption from the oral mucosa or intending for immediate pharmacological action can be formulated as ODT dosage forms. Rasagiline, a second generation, selective, irreversible inhibitor of mono amine oxidase type B drug, is primaril...

The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression te...

In the present investigation, the compatibility of Atorvastatin calcium was evaluated with various superdisintegrants and other solid excipients by means of FT-IR and DSC. Several batches of tablets with varying proportion of superdisintegrants were prepared by direct compression techniques. Tablets were also evaluated for different physical properties and in-vitro drug release characteristics ...