BACKGROUND Development of new drug carriers would be an interesting approach if it allowed increased efficacy of antibiotics and a reduction in doses, thus reducing the risk of developing resistance. As with most drug carriers, niosomes have been used to improve the selective delivery and the therapeutic index of antimicrobial agents. METHODS In this study, different formulation of niosomes c...

Oil entrapped floating alginate beads of curcumin were developed and characterized. Cremophor EL, Cremophor RH and Tween 80 were utilized to improve the solubility of the drug. The oil-loaded floating gel beads prepared by emulsion gelation method contained sodium alginate, mineral oil and surfactant. The drug content and % encapsulation declined as the ratio of surfactant was increased. The re...

Self-emulsifying drug delivery systems (SEDDS) were prepared by dissolving Cremophor EL, Tween 20, Tween 80 and Span 80 (1% or 5%) in oils (Miglyol 812 or castor oil). Solubilities of three ophthalmic drugs, namely aciclovir, hydrocortisone and indomethacin were determined in these systems. In addition, the effect of a small amount of water (0.5% and 2%) on solubilization properties of the syst...

Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and...

Alone and combined effects of cyclodextrins (βCD and HPβCD), surfactant (Tween-80) and PVP on the solubility and dissolution rate of etoricoxib were evaluated in a series of 2 factorial design. The complexes of etoricoxib – CDs (βCD and HPβCD) were prepared with and without Tween-80 and PVP by kneading method as per 2 factorial designs. The solubility of etoricoxib in eight selected fluids cont...

Normal micelle microemulsion method was utilized for fabrication of organically modified silica (ORMOSIL) nanoparticles. The void and dye-doped nanoparticles were synthesized in nonpolar core of two different surfactants including Aerosol OT and Tween 80. The nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, and zeta potential analysis. Our resul...

Calcium carbonate nano-particles were synthesized by a reverse micro-emulsion method at room temperature with Tween® 80 and Span® 80 as co-surfactants. The nano-particles synthesized were surface modified by stearic acid. An important operating variable in the Span 80-Tween 80/toluene/water reverse micro-emulsion system, the ω-value (water/surfactant molar ratio) was i...

copper sulfate was used as a precursor to prepare cuo nanoparticles in reverse micelles (o/w microemulsion).  this is a technique which allows the preparation of ultrafine metal oxide nanoparticles within the size ranging from 50 to 60 nm. the preparation of nano copper (ii) oxide studied was investigated in the inverse microemulsion system. therefore the nucleation of metal particles proceeds ...

Wheat straw is a suitable raw material for ethanol production since it has high cellulose content. The objective of this work was to evaluate the effect of cellobiase and surfactant on the enzymatic hydrolysis of lignocellulosic materials. For this purpose, wheat straw was first pretreated by organosolv digestion. The chemical compositions of raw and pretreated wheat straw were analyzed. Much o...

The present work was conducted on the effect of surfactant on the dissolution rate of ibuprofen tablets. The cationic (Cetyl Trimethyl bromide) and anionic (Sodium dodecyl sulphate) surfactant present in the dissolution media have remarkable effect on the dissolution rate of Ibuprofen. Maximum dissolution was obtained in the presence of anionic surfactant (Sodium dodecyl sulphate) at 0.5% conce...