Response-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARtool software can compute different types of optimal treatment allocation designs, and it can simu...

PURPOSE To investigate the relationship between early treatment response to definitive chemoradiotherapy (CRT) and survival outcome in patients with limited stage small cell lung cancer (LS-SCLC). MATERIALS AND METHODS We retrospectively reviewed 47 patients with LS-SCLC who received definitive CRT between January 2009 and December 2012. Patients were treated with systemic chemotherapy regime...

Traditional Intrusion Detection Systems (IDSs) mostly work off-line, without any direct runtime interaction or coordination with the applications (and with other IDSs) that they aim to protect. Including intrusion detection and response in the repertoire of an adaptive application extends its range of adaptivity and increases its chances for survival. In this paper we show how intrusion detecti...

an adaptive version of growing and pruning rbf neural network has been used to predict the system output and implement linear model-based predictive controller (lmpc) and non-linear model-based predictive controller (nmpc) strategies. a radial-basis neural network with growing and pruning capabilities is introduced to carry out on-line model identification.an unscented kalman filter (ukf) algor...

Substantial evidence indicates that adaptive response induced by low doses of ionizing radiation can result in resistance to the damage caused by a subsequently high-dose radiation or cause cross-resistance to other non-radiation stressors. Adaptive response contradicts the linear-non-threshold (LNT) dose-response model for ionizing radiation. We have previously reported that exposure of labora...

White spot syndrome virus (WSSV) occurs worldwide and causes high mortality and considerable economic damage to the shrimp farming industry. No adequate treatments against this virus are available. It is generally accepted that invertebrates such as shrimp do not have an adaptive immune response system such as that present in vertebrates. As it has been demonstrated that shrimp surviving a WSSV...

The CD40-CD40 ligand (CD40L) interaction is a key event in the initiation of an adaptive immune response, and as such the therapeutic value of CD40L blockade has been studied in many experimental models of tissue transplantation and autoimmune disease. In rodents, transplantation of allogeneic tissues under the cover of anti-CD40L Abs has resulted in prolonged graft survival but not tolerance. ...

the purpose of this study was to describe the feasibility of a combined preoperative chemoradiation program ib-iia, bulky and suspicious iib by radical surgery in patients with stage ib-iib cervical cancer. from september 1999 to april 2002, 30 patients with carcinoma of the cervix were treated with preoperative external beam radiotherapy of 45 gy in 5 weeks. patients received concurrent contin...

BACKGROUND Response-adaptive randomisation designs have been proposed to improve the efficiency of phase III randomised clinical trials and improve the outcomes of the clinical trial population. In the setting of failure time outcomes, Zhang and Rosenberger (2007) developed a response-adaptive randomisation approach that targets an optimal allocation, based on a fixed sample size. OBJECTIVES ...