Among proteins utilized as sweeteners, neoculin and miraculin are taste-modifying proteins that exhibit pH-dependent sweetness. Several experiments on neoculin have shown that His11 of neoculin is responsible for pH dependence. We investigated the molecular mechanism of the pH dependence of neoculin by molecular dynamics (MD) calculations. The MD calculations for the dimeric structures of neocu...

[This corrects the article DOI: 10.1186/s13690-015-0092-x.].

Aspartame (NutraSweet--The NutraSweet Co., Deerfield, IL) an artificial intense sweetener, was tested for its cariogenicity alone and in the presence of sucrose. Sprague-Dawley rat pups (Charles River Laboratories, Bloomington, MA) inoculated with Streptococcus mutans were fed basal diet 2000 with one of the following added: 50% sucrose; 30% sucrose; 30% sucrose + 0.15% aspartame; 0.30% asparta...

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Saccharin (o-sulfobenzimide; 1,2-benzothiazole-3(2H)-one 1,1 dioxide; Hsac, Figure 1) is one of the best known and most widely used artificial sweetening agents. Initially, investigation of the interaction of saccharin with different biologically relevant cations attracted great interest due to the suspected carcinogenicity of this compound which, notwithstanding, was recently definitively rule...

Although dental caries appears to be almost universal disease, rampant caries in the infant and very young children is one of the most frustrating and difficult conditions to treat. It exacts an alarming toll in terms of the child’s comfort, health and development. Milk in particular is responsible for major account of the damage, although pacifiers and nipples dipped in sweetening agents will ...