Background: Synthetic radio-protective agents like aminothiols are toxic and FDA approved agent amifostine is no exception. Some Ayurvedic herbs have shown radioprotective potential. This study was carried out to test and compare the radioprotective potential of Curcuma longa (CL) Tinospora cordifolia (TC), Zizyphus mauritiana (ZM) and Ocimum sanctum (OS) against 2Gy gamma irradiation ...

The aim of this study was to evaluate antitumour activity of the roots of Hibiscus tiliaceus Linn. against Dalton’s Ascitic Lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time (MST) of H. tiliaceus treated tumour bearing mice was found with respect to control group. H. tiliaceus treatment was found to enhance peritoneal cell counts. When these H. ti...

Intraperitoneal inoculation of mouse K papovavirus into infant (2 to 4 days old) Swiss albino mice produced a high-titered viremia which persisted until death due to pneumonitis on day 9 postinfection. Lungs and livers of these mice had virus-specific immunofluorescence and histological lesions. K-virus antibody was undetectable. Three- to four-week-old mice, although as susceptible to infectio...

Background: The high saturated fatty acid content of beef has been linked to obesity and cardiovascular diseases. study investigated the impact black seed oil (BSO) on fat-altered hemato-biochemical pathophysiological alterations in albino mice. Methods: Twenty four Swiss Albino mice (Mus musculus) 25-28 days old were equally divided into three groups (n=8) namely A, B C. Mice group A was desig...

This study was designed to determine the in vitro anticancer potential of Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer swiss albino mice. The activity assessed using cytotoxicAity, mean survival time, tumor volume and hematological studies. reliable criteria for evaluating any agent is prolongation lifespan animal decrease WBC count b...

The aim of the present study is to evaluate the effect of ethanolic extract of leaves of Leptadenia reticulata leaves (LELR) against Dalton’s Ascitic Lymphoma (DAL) in Swiss Albino mice. DAL cells were injected intraperitoneally (106 cells/mouse) to the mice. Two days after cells injection the animals were treated with 200 mg/kg of LELR for 8 days. Five-fluorouracil (20 mg/kg) was used ...

The present study describes anticancer effect of gallic acid based indanone derivative (1). Indanone 1 exhibited in vivo anticancer activity against Erhlich ascites carcinoma in Swiss albino mice by inhibiting tumor growth by 54.3% at 50 mg/kg b.wt. It showed antitubulin effect by inhibiting tubulin polymerase enzyme. In cell cycle analysis, it inhibited G2/M phase and induced apoptosis. It sig...

The present study reports the effect of Spirulina on radiation induced hematological and biochemical alterations in Swiss albino mice. Animals of Group-I (Control, radiation alone) were exposed to gamma radiation (8 Gy), while, animals of Group-II (Experimental, Spirulina + Radiation), received Spirulina (800 mg/kg body weight) for seven consecutive days and were exposed to gamma radiation (as ...

Portulaca quadrifida Linn. has been evaluated for its hepatoprotective activity in Swiss albino mice using the mercury induced hepatotoxicity. The ethanolic extract showed remarkable activity against mercury-induced hepatotoxicity as judged from biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and levels of lipid...

Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.