Roots of the plant were collected at mukkombu, Trichy Dt., Tamilnadu shade dried, powdered and finally extracted with methanol in a soxhlet. The extract was evaporated to dryness and dissolved in phosphate buffer (pH 7.4) and used for the present investigation and phytochemical screening. Swiss albino mice having body weight between 20-24g were selected for the present investigation. The animal...

Givotia rottleriformis has been used in the indigenous systems of medicine for the treatment of inflammatory diseases like rheumatism and psoriasis. In order to evaluate this information, antipsoriatic activity of three flavonoids isolated from the ethanol extract of the bark of Givotia rottleriformis were investigated using in-vitro and in-vivo model, namely Rutin (I), Luteolin-7-O-β-D-Glucuro...

Swiss albino and C57BL/10 eggs from induced ovulations, and spontaneously ovulated A eggs, were activated in vitro by a heat shock of 44 degrees C for 5 to 7-5 min and cultured in the presence of 10 mug/ml of Cytochalasin B (CB) for 5-8 h. The activation rate was about 70% in Swiss albino, 40% in C57BL and 90% in A eggs. CB suppressed second polar body (2P.B.) formation in over 90% of activated...

  Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice.   Materials and Methods:   Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the ...

The present investigation was undertaken to explore the Antimutagenicity activity of Terminalia chebula on micronucleus formation and chromosomal aberration assay in bone marrow cells of Swiss albino mice. The protective effect of Terminalia chebula extract is reported against cyclophosphamide (CP)-induced micronuclei formation and chromosomal aberration in mouse bone marrow cells. The doses na...

We have often observed small dense bodies in the cytoplasm of cells of the stratum granulosum during a study of the fine structure of normal and experimentally altered mouse ear epidermis. Odland (10) noted their presence in human epidermis, showed that they have an internal structure, and speculated that they may be degenerating mitochondria. Other authors seem to have overlooked them in their...

Purpose: To evaluate the effect of vitamin B-complex on the nephrotoxicity of gentamicin in an established rat model. Methods: Adult Swiss albino rats weighing 170±20g were divided into 4 groups of 4 rats each. Each group was given one of the following: placebo injection (Control), 80mg/kg of gentamicin sulphate alone or with 1.5ml/kg/3ml/kg body weight of vitamin B-complex (intramuscular) cont...

The effect of coccoid forms of a vaculating cytotoxin A positive Helicobacter pylori strain on Mus musculus (Swiss mice) and Rattus norvegicus (Albino rats) was studied. Two groups of Swiss mice and Albino rats were used. The first group of mice and rats was orally inoculated with coccoid forms of Helicobacter pylori, whereas, the second group of mice and rats were untreated and used as a contr...