Adenosine is currently being investigated as a possible mediator of a homeostatic sleep need. Reports from different laboratories suggest that both adenosine A1 agonists and selective serotonin reuptake inhibitors (SSRI) increase deep slow wave sleep (SWS-2) after an interval. In this study, the sleep-wake effects of the adenosine A1 agonist N6-cyclopentyladenosine (CPA) and the SSRI zimeldine ...

The Drosophila Swiss Cheese (SWS) protein and its vertebrate ortholog Neuropathy Target Esterase (NTE) are required for neuronal survival and glial integrity. In humans, NTE is the target of organophosphorous compounds which cause a paralyzing axonal degeneration and recently mutations in NTE have been shown to cause a Hereditary Spastic Paraplegia called NTE-related Motor-Neuron Disorder. SWS ...

Web Services (WS) are software modules that perform operations that are network-accessible through XML messaging. Web Services in the Semantic Web, that is, Semantic Web Services (SWS), should describe semantically their structure and capabilities to enable its automatic discovery, invocation and composition. In this work we present a development environment to design SWS in a language-independ...

BACKGROUND Communities across the United States are using street outreach workers (SWs) to prevent violence. SW programs are generally recognized as a promising model, particularly in light of a 2008 evaluation that demonstrated positive impacts associated with one well-known program. The United Teen Equality Center (UTEC) includes an SW program. OBJECTIVES Through this paper we aim to (1) do...

The three vigilance states (wakefulness [W], slow wave sleep [SWS], rapid eye movement sleep [REMS]) are controlled by distinct, but interconnected, networks of neurons. The sleep/arousal network consists of separate systems of W-promoting and SWS-promoting neurons, located in nuclei in the basal forebrain, diencephalon and brainstem. Each neuronal system operates via a distinct neurotransmitte...

BACKGROUND Community mobilization among female sex workers (SWs) is recognized as an effective strategy to empower SWs and increase their uptake of health services. Activities focus on increasing social cohesion between SWs by building trust, strengthening networks, and encouraging shared efforts for mutual gain. Several studies, however, suggest that high levels of interpersonal competition be...

Semantic web services (SWS) promise to take service oriented computing to a new level by allowing to semi-automate timeconsuming programming tasks. At the core of SWS are solutions to the problem of SWS matchmaking, i.e., the problem of comparing semantic goal descriptions with semantic offer descriptions to determine services able to fulfill a given request. Approaches to this problem have so ...

Homologous recombination (HR) repairs cytotoxic DNA double-strand breaks (DSBs) with high fidelity. Deficiencies in HR result in genome instability. A key early step in HR is the search for and invasion of a homologous DNA template by a single-stranded RAD-51 nucleoprotein filament. The Shu complex, composed of a SWIM domain-containing protein and its interacting RAD51 paralogs, promotes HR by ...

Sleep problems are commonly reported in Rett syndrome (RTT); however the electroencephalographic (EEG) biomarkers underlying sleep dysfunction are poorly understood. The aim of this study was to analyze the temporal evolution of quantitative EEG (qEEG) biomarkers in overnight EEGs recorded from girls (2-9 yrs. old) diagnosed with RTT using a non-traditional automated protocol. In this study, EE...

Semantic Web Services (SWS) aim at the automated discovery, selection and orchestration of Web services on the basis of comprehensive, machine-interpretable semantic descriptions. However, heterogeneities between distinct SWS representations pose strong limitations w.r.t. interoperability and reusability. Hence, semantic-level mediation, i.e. mediation between concurrent semantic representation...