Eco-systemic disconnect in youth entrepreneurs' support systems is a challenge most developing countries and adversely affects the success of entrepreneurship education. The study investigated extent to which application systemic action learning research (SALAR) students' entrepreneurial self-efficacy (ESE) determined relationships between ESE development, intention action. A quantitative desig...

Abstract This paper discusses the novelty of Aleksandr Bogdanov’s approach, which combines systemic perspectives employed in his Tektology , general science organization (1913–1922). In this work, Bogdanov places particular emphasis on concept environment and situates process ‘organization’ a shared social context. The interaction among agents, between them their contextual surroundings, implie...

Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis on trabectedin. Trabectedin is a unique type of chemotherapeutic agent with multiple potential mechanisms of action. We discuss the putative mechanisms, as well as the toxici...

Relief of angina by nitroglycerine has been attributed to two possible mechanisms: (1) Increase in myocardial blood supply by direct acton of the drug on the coronary arteries. (2) Reduction in myocardial oxygen demand by action of the drug on the systemic circulation. Sublingual application of nitroglycerin in previous studies did not allow the ruling out of the operation of either or both mec...