Periodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding tooth. Routine periodontal treatment includes mechanical debridement (surgical non-surgical) systemic administration antibiotics. In contrast, severe chronic periodontitis aggressive tissue bone resorption, damage usually irreversible. these cases, grafts, delivery growth hormones, guide...

Paeoniflorin (PF) is an active glucoside in Shaoyao (peony root), and is transformed into an antispasmodic metabolite, paeonimetabolin-I (PM-I), by intestinal bacteria in the gut after oral administration of Shaoyao or Shaoyao-Gancao-tang (SGT, Shakuyaku-Kanzo-To in Japanese). SGT is a pain-relieving traditional Chinese formulation (Kampo-medicine in Japanese) and is often used together with an...

To understand the application of antibacterial agents in aseptic operations and to provide evidence for their rational use and management, the antibiotic use statuses of six types of aseptic operations (306 cases from 4 tertiary hospitals) were retrospectively analyzed. Of 312 patients, 306 (65.08%) were treated with antibacterial agents in the perioperative period. Four categories of antibioti...

background: college student community is the one with high risk of tuberculosis (tb). a systemic and standardized administration model for prevention and control of tb is significance in controlling tb spread in universities. currently, the universities in china have not established the comprehensive and standardized administration system for tb prevention and control in college student communi...

Staphylococcus aureus infections are associated with considerable morbidity and, in certain situations, mortality. The association between the nasal carriage of S. aureus and subsequent infection has been comprehensively established in a variety of clinical settings, in particular, patients undergoing haemodialysis and continuous ambulatory peritoneal dialysis (CAPD), and in patients undergoing...

Acute respiratory distress syndrome (ARDS) is a pulmonary syndrome with growing prevalence and high mortality and morbidity that increase with age. There is no current therapy able to restore pulmonary function in ARDS patients. Preclinical models of ARDS have demonstrated that intratracheal or systemic administration of mesenchymal stem cells (MSCs) protects the lung against injury. The mechan...

Peptoids are peptidomimetic polymers that are resistant to proteolysis and less prone to immune responses; thus, they can provide a practical alternative to peptides. Among the various therapeutic applications that have been explored, cationic amphipathic peptoids have demonstrated broad-spectrum antibacterial activity, including activity towards drug-resistant bacterial strains. While their po...

Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats. Methods: A total of 201 male Wistar rats weighing 260-310 g were used in...

INTRODUCTION Implant-associated infection, although rare, has been one of main complications accompanied by orthopedic implant surgeries including prosthetic joint replacement and fracture fixation. The number of such infections has continuously increased with growing demands for surgical implantation due to population aging and increased participation in outdoor activities. The established inf...