CLINICAL CASE We present a case of a 67-year-old female suffering for bilateral conjunctival oedema that did not improve with antibiotic and antiinflammatory treatment. After a complete systemic examination she was diagnosed with an adrenal adenocarcinoma and treated by surgery and chemotherapy. The conjunctival chemosis subsequently improved. Unfortunately the patient died of respiratory failu...

BACKGROUND Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS Between 2003 and 2013, 55 patients with bacterial brain abscesses (83 abscesses) were tr...

Three chemotherapy-induced neutropenic hematologic patients with severe systemic infection caused by Fusobacterium nucleatum, a Gram-negative anaerobic rod, are described. Anaerobic infections are not very common in this patient category, but in a short period of time, several such patients were seen. The infection was considered to be caused by a combination of chemotherapy-induced mucositis, ...

conclusions due to the increasing resistance of pathogens to usual empirical antibiotics, it is reasonable to stress upon preventive measures, so that a minimum number of neonates develop sepsis. results coagulase-negative staphylococci (cons) were the most prevalent pathogens isolated from blood specimens in early and late-onset disease. escherichia coli and klebsiella were the most causative ...

We have assessed the effect of different regimes of antibiotic prophylaxis on the survival of total hip implants, comparing antibiotics administered both systemically and in the bone cement, systemically only, in the bone cement only and with no antibiotics given. We studied 10 905 primary cemented total hip replacements, performed for osteoarthritis of the hip and reported to the Norwegian art...

treatment (1). But, local implantable delivery with sustained antibiotic release may offer considerable advantages over the traditional method of therapy by producing an effective local antibiotic concentration at the diseased site, with the limitation of systemic exposure to antibiotics maintaining low systemic side effects (2). Hydroxyapatite (HAp, [Ca10(PO4)6(OH)2]) is one of the widely used...

Mastoiditis is a common complication of acute otitis media. It in younger age compared to adulthood. occurs when an media infection spread directly involve the bone mastoid air cell causing osteitis. Cholesteatoma can contribute development mastoiditis. This typically leads breakdown some fine bony trabeculae cells producing coalescent mastoiditis with emphyema antrum. The treatment for intrave...

BACKGROUND In recent years, cranial ventricular catheters impregnated with antimicrobial agents have become available. Theoretically, they provide antibiotic prophylaxis locally without the associated complications of opportunistic nosocomial infections. This study aims to compare antibiotic impregnated catheters with conventional catheters coupled with systemic antibiotics. METHODS Patients ...

When using a staged approach to eradicate chronic infection after total hip replacement, systemic delivery of antibiotics after the first stage is often employed for an extended period of typically six weeks together with the use of an in situ antibiotic-eluting polymethylmethacrylate interval spacer. We report our multi-surgeon experience of 43 consecutive patients (44 hips) who received syste...

Severe melioidosis is a life-threatening, systemic bacterial infection caused by Burkholderia pseudomallei. A prospective, randomized treatment trial was conducted in northeast Thailand to compare ceftazidime (a penicillin-binding protein [PBP]-3-specific agent that causes release of large amounts of endotoxin in vitro) and imipenem (a PBP-2-specific agent that kills B. pseudomallei more rapidl...