and multiple organ failure caused by infections correlate with high mortality. In infections with gram-negative bacteria, these systemic inflammatory responses are caused by lipopolysaccharide (LPS), the major component of the outer membrane. LPS triggers the production of various cytokines (TNF-a , IL-1b and IL-6 etc.), chemokines (IL-8 and monocyte chemoattractant protein 1 etc.), and biologi...

Communications to the Editor clinical picture is similar to that produced by other organisms, such as mycobacteria, although Nocardia is also capable of inducing a granulomatous reaction in tissue. This gives rise to the possibility of making an erroneous diagnosis of tuberculosis, above all in areas such as Spain where this disease is relatively frequent. Although ceftriaxone has been shown to...

OBJECTIVE Low doses of acetyl salicylic acid, acting through 15-epi-lipoxin A4, have been shown to be anti-inflammatory in human studies. The manifold effects of acetyl salicylic acid on human physiology potentially may benefit patients with the systemic inflammatory response syndrome after sepsis or tissue trauma. We sought to determine whether acetyl salicylic acid administration at the time ...

BACKGROUND Ticagrelor is a reversible and direct-acting oral antagonist of the adenosine diphosphate receptor P2Y12. Possible adenosine-mediated effects of ticagrelor on inflammation are complex and incompletely understood. To our knowledge, ticagrelor-induced systemic inflammatory response syndrome (SIRS) has not yet been described. CASE PRESENTATION We report the case of an 84 years old pat...

Sepsis is defined as a suspected or proven infection in the systemic inflammatory response syndrome (SIRS) . From the beginning of a systemic infection and over sepsis peaks of immune-mediators characteristic of SIRS and for the compensatory anti-inflammatory response syndrome (CARS) may be seen in sequence or in parallel 2 that enlighten the reason why broad investigation of inflammatory bioma...

This article deals with optimal control applied to vaccination and treatment strategies for an SIRS epidemic model with logistic growth and delay. The delay is incorporated into the model in order to modeled the latent period or incubation period. The existence for the optimal control pair is also proved. Pontryagin's maximum principle with delay is used to characterize these optimal controls. ...

We consider a two-patch epidemiological system where individuals can move from one patch to another, and local interactions between the individuals within a patch are governed by the classical SIRS model. When the time-scale associated with migration is much smaller than the time-scale associated with infection, aggregation methods can be used to simplify the initial complete model formulated a...

Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme de...