Variations in systemic arterial pressure with positive-pressure breathing are frequently used to guide fluid management in hemodynamically unstable patients. However, because of the complex physiology that determines the response, there are important limitations to their use. Two papers in a previous volume add pulmonary hypertension as limitations. Uncritical use of ventilatory-induced changes...

chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. ...

The antitumoral effects of oncolytic viruses have generally been limited by inefficient spread of the viruses within infected tumors and by inefficient systemic delivery, particularly in preimmunized hosts. Tumor-selective poxviruses have biological characteristics that may overcome these limitations. Nevertheless, physical barriers within the tumor microenvironment, including the extracellular...

OBJECTIVE To identify, evaluate, and review randomized controlled trials (RCTs) on the treatment of sudden sensorineural hearing loss (SSHL). DATA SOURCES A MEDLINE search and hand search were conducted to identify RCTs published between January 1966 and February 2006 in the English language on the treatment of SSHL. Search terms included hearing loss, sensorineural (MeSH term), sensorineural...

Metastatic spread of the primary is still defined as the systemic stage of disease in treatment guidelines for various solid tumors. This definition is the rationale for systemic therapy. Interestingly and despite the concept of systemic involvement, surgical resection as a local treatment has proven to yield long-term outcomes in a subset of patients with limited metastatic disease, supporting...

paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and carotid bifurcation, the latter two fonns being coined as chemodectomas. the vertebral column, especially the llullbar zone, is one of the rarest sites to be involved by paragangliomas. these lesions may have secretory functio...

introduction : due to the increased prevalence of medically compromised patients who require dental treatments, it is a crucial task for dentists and dental specialists to prepare themselves for emergent professional situations. this study was performed to determine the prevalence of different medical problems among a population of patients admitted to a dental educational center. materials and...