Foxp3 is required for the generation and activity of CD4(+)CD25(+) regulatory T (T reg) cells, which are important controllers of autoimmunity, including type-1 diabetes. To determine where T reg cells affect the diabetogenic cascade, we crossed the Foxp3 scurfy mutation, which eliminates T reg cells, with the BDC2.5 T cell receptor (TCR) transgenic mouse line. In this model, the absence of T r...

This paper explores ‘mobilities’ as a research framework for learning not so much in terms of what has to be done to enhance learning using mobile technologies. Instead it focuses on our ways of knowing and learning by ‘being mobile’. It suggests a practice perspective for learning by ‘setting in motion’ not just technologies, but also bodies and spaces. It seeks to understand what is being don...

E ven 127 years after Robert Koch’s identification of Mycobacterium tuberculosis as the causative agent of tuberculosis (TB), the diagnosis of active disease still depends in many parts of the world on the same tools that Koch has used: specifically staining of the bacilli and visual observation by microscopy [1]. Thirty years later, von Pirquet developed the tuberculin skin-test (TST), which, ...

Since the creation of the World Health Organization’s nasal natural killer (NK)/T-cell lymphoma category, the attempt to further classify, describe, and improve treatment in this entity has been underway. There has been quite a bit of confusion and frustration regarding diagnosis, staging, and treatment approaches. With his article in this issue of ONCOLOGY, Dr. Au has attempted to improve our ...