The Set1 complex, a histone methyltransferase complex found in S. cerevisiae (budding yeast), is the only histone methyltransferase responsible for catalyzing methylation of histone H3 at Lysine 4. It possesses homologues in other species, humans included. While yeast only have the Set1 complex, the human homologues of the yeast Set1 complex include mixed-lineage leukemia family (MLL1-4), Set1 ...

micrornas (mirnas) are short rna molecules which bind to target mrnas, resulting in translational repression and gene silencing and are found in all eukaryotic cells. approximately 2200 mirna genes have been reported to exist in the mammalian genome, from which over 1000 belong to the human genome. many major cellular functions such as development, differentiation, growth, and metabolism are kn...